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Titolo:
FAILURE TO DETECT BORNA-DISEASE VIRUS-INFECTION IN PERIPHERAL-BLOOD LEUKOCYTES FROM HUMANS WITH PSYCHIATRIC-DISORDERS
Autore:
RICHT JA; ALEXANDER RC; HERZOG S; HOOPER DC; KEAN R; SPITSIN S; BECHTER K; SCHUTTLER R; FELDMANN H; HEISKE A; FU ZF; DIETZSCHOLD B; ROTT R; KOPROWSKI H;
Indirizzi:
THOMAS JEFFERSON UNIV,CTR NEUROVIROL PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,CTR NEUROVIROL PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,BIOTECHNOL FDN LABS,DEPT IMMUNOL & MICROBIOL PHILADELPHIA PA 19107 UNIV GIESSEN,INST VIROL D-6300 GIESSEN GERMANY UNIV PENN,DEPT PSYCHIAT,CTR STUDIES ADDICT PHILADELPHIA PA 19104 BEZIRKSKRANKENHAUS GUNZBURG GUNZBURG GERMANY UNIV ULM,BEZIRKSKRANKENHAUS,DEPT PSYCHIAT 2 GUNZBURG GERMANY UNIV MARBURG,INST VIROL D-3550 MARBURG GERMANY
Titolo Testata:
Journal of neurovirology
fascicolo: 2, volume: 3, anno: 1997,
pagine: 174 - 178
SICI:
1355-0284(1997)3:2<174:FTDBVI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; MONONUCLEAR-CELLS; RNA; ANTIBODIES; HORSES;
Keywords:
BORNA DISEASE VIRUS; PSYCHIATRIC DISEASE; PBLS; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Richt et al., "FAILURE TO DETECT BORNA-DISEASE VIRUS-INFECTION IN PERIPHERAL-BLOOD LEUKOCYTES FROM HUMANS WITH PSYCHIATRIC-DISORDERS", Journal of neurovirology, 3(2), 1997, pp. 174-178

Abstract

The presence of antibodies reactive with Borna disease virus (BDV) inthe sera of some patients with certain psychiatric illnesses has beentaken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper,we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity ofRT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:07:31