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Titolo:
DIFFERENCES IN THE SYNAPTIC COMPLEMENT OF THORACIC MOTONEURONS OF ADULT AND AGING CATS AFTER PERMANENT OR REVERSIBLE AXOTOMY
Autore:
JOHNSON IP; GOWDA CK; SEARS TA; HUNTER AS;
Indirizzi:
ROYAL FREE HOSP,SCH MED,DEPT ANAT & DEV BIOL,ROWLAND HILL ST LONDON NW3 2PF ENGLAND UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT ANAT LONDON E1 4NS ENGLAND UMDS,DEPT PHYSIOL LONDON ENGLAND UMDS,DEPT ANAT LONDON ENGLAND
Titolo Testata:
Synapse
fascicolo: 2, volume: 28, anno: 1998,
pagine: 176 - 184
SICI:
0887-4476(1998)28:2<176:DITSCO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL ALPHA-MOTONEURONS; HORSERADISH-PEROXIDASE; HYPOGLOSSAL NUCLEUS; SKELETAL-MUSCLE; GAMMA-MOTONEURONS; AXONAL-TRANSPORT; MOTOR NEURONS; AGING RAT; NERVE; REGENERATION;
Keywords:
CYTOLOGY; NERVE REGENERATION; ULTRASTRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
I.P. Johnson et al., "DIFFERENCES IN THE SYNAPTIC COMPLEMENT OF THORACIC MOTONEURONS OF ADULT AND AGING CATS AFTER PERMANENT OR REVERSIBLE AXOTOMY", Synapse, 28(2), 1998, pp. 176-184

Abstract

We have compared the effects of intercostal nerve crush (reversible axotomy) or nerve transection with proximal ligation (permanent axotomy) on the somatic synaptic terminals of thoracic motoneurons of adult (1-2 years) and ageing (10-15 years) cats. Retrograde axonal transport of horseradish peroxidase (HRP) was used to identify axotomised motoneurons; control motoneurons were labelled by the intramuscular injection of HRP. Synaptic frequency and cover of control motoneurons in adultand ageing cats was similar. In adults, 8-16 days following both types of axotomy, synaptic cover was halved without any significant changein synaptic frequency. By 32-64 days following reversible axotomy, synaptic frequency and cover were not significantly different from controls. By contrast, 32-64 days following permanent axotomy synaptic frequency and cover mere reduced to 30-50% of adult control values. In ageing cats 2 months following reversible axotomy, synaptic frequency andcover were reduced to 40% and 33% of ageing control values, respectively, while no significant change from controls was found 2 months following permanent axotomy. The long-term synaptic response of axotomisedmotoneurons in ageing cats is therefore opposite to that of adults. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:24:49