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Titolo:
TRYPTOPHAN-HYDROXYLASE AND CATECHOL-O-METHYLTRANSFERASE GENE POLYMORPHISMS - RELATIONSHIPS TO MONOAMINE METABOLITE CONCENTRATIONS IN CSF OFHEALTHY-VOLUNTEERS
Autore:
JONSSON EG; GOLDMAN D; SPURLOCK G; GUSTAVSSON JF; NIELSEN DA; LINNOILA M; OWEN MJ; SEDVALL GC;
Indirizzi:
KAROLINSKA INST,PSYCHIAT SECT,DEPT CLIN NEUROSCI SE-17176 STOCKHOLM SWEDEN NIAAA,NEUROGENET LAB,DIV INTRAMURAL CLIN & BIOL RES ROCKVILLE MD 20892 UNIV WALES COLL MED,INST MED GENET CARDIFF CF4 4XN S GLAM WALES NIAAA,CLIN STUDIES LAB,DIV INTRAMURAL CLIN & BIOL RES BETHESDA MD 20892
Titolo Testata:
European archives of psychiatry and clinical neuroscience
fascicolo: 6, volume: 247, anno: 1997,
pagine: 297 - 302
SICI:
0940-1334(1997)247:6<297:TACGP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; PREMENSTRUAL-SYNDROME; PHARMACOGENETICS; CHROMOSOME-22; FLUOXETINE; STEROIDS; RAT;
Keywords:
TRYPTOPHAN HYDROXYLASE GENE; CATECHOL-O-METHYLTRANSFERASE GENE; MONOAMINE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Jonsson et al., "TRYPTOPHAN-HYDROXYLASE AND CATECHOL-O-METHYLTRANSFERASE GENE POLYMORPHISMS - RELATIONSHIPS TO MONOAMINE METABOLITE CONCENTRATIONS IN CSF OFHEALTHY-VOLUNTEERS", European archives of psychiatry and clinical neuroscience, 247(6), 1997, pp. 297-302

Abstract

Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated possible relationships between DNA polymorphisms in the tryptophan hydroxylase (TPH) and catechol-O-methyltransferase (COMT) genes and CSF concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = = 66). Lower CSF 5-HIAA levels were found in men with the TPH U allele (p = 0.005), but not in women. A similar but less significant pattern was observed for CSF HVA. No relationship was found between the TPH polymorphism and CSF MHPG. COMT genotypes did not relate significantly to MM concentrations. The results suggest that TPH genotypes participate differentially in the regulation of serotonin turnover rate under presumed steady state in the central nervous system of men. Due to the uncertain functional relevance of the DNA polymorphism investigated and the many calculations performed, the results should be interpreted with caution until replicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:58:50