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Titolo:
HUMAN RECOMBINANT TISSUE-FACTOR PATHWAY INHIBITOR PREVENTS THE PROLIFERATION OF CULTURED HUMAN NEONATAL AORTIC SMOOTH-MUSCLE CELLS
Autore:
KAMIKUBO Y; NAKAHARA Y; TAKEMOTO S; HAMURO T; MIYAMOTO S; FUNATSU A;
Indirizzi:
CHEMOSEROTHERAPEUT RES INST,1-6-1 OKUBO KUMAMOTO 860 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 407, anno: 1997,
pagine: 116 - 120
SICI:
0014-5793(1997)407:1<116:HRTPIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
3RD KUNITZ DOMAIN; FACTOR-XA; COAGULATION INHIBITOR; ENDOTHELIAL-CELLS; PLATELET FACTOR-4; GROWTH-FACTOR; HEPARIN; RESTENOSIS; PURIFICATION; ABSENCE;
Keywords:
TISSUE-FACTOR PATHWAY INHIBITOR; RESTENOSIS; HUMAN NEONATAL AORTIC SMOOTH MUSCLE CELL; TISSUE FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kamikubo et al., "HUMAN RECOMBINANT TISSUE-FACTOR PATHWAY INHIBITOR PREVENTS THE PROLIFERATION OF CULTURED HUMAN NEONATAL AORTIC SMOOTH-MUSCLE CELLS", FEBS letters, 407(1), 1997, pp. 116-120

Abstract

Tissue-factor pathway inhibitor (TFPI) inhibits the procoagulant activity of the tissue-factor/factor VIIa complex, It mas recently reported that TFPI prevented restenosis following tissue injury in a rabbit atherosclerotic model, In order to clarify the mechanism behind this successful prevention of restenosis, we investigated the direct effect of human recombinant TFPI (h-rTFPI) on the proliferation of cultured human neonatal aortic smooth muscle cells (hSMC), We found that h-rTFPI exhibits inhibitory activity toward hSMC proliferation, while h-rTFPI-C which lacks the carboxyl (C)-terminal region does not, Furthermore, we found that h-rTFPI binds to hSMCs with K-d = 526 nM but that this binding is inhibited by the addition of the synthetic C-terminal peptide, Lys(254)-Met(276), to h-rTFPI. Thus, the interaction of h-rTFPI with hSMCs mediated via the C-terminal region is responsible for the anti-proliferative action of h-rTFPI, On the basis of these results, ne presume that the anti-proliferative effect of h-rTFPI in addition to itsanticoagulant function plays a significant role in preventing restenosis following tissue injury. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 18:54:21