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Titolo:
LOCALIZATION OF DOPAMINE-RECEPTOR SUBTYPES IN CORPUS STRIATUM AND NUCLEUS-ACCUMBENS-SEPTI OF RAT-BRAIN - COMPARISON OF D-1-LIKE, D-2-LIKE, AND D-4-LIKE RECEPTORS
Autore:
TARAZI FI; CAMPBELL A; YEGHIAYAN SK; BALDESSARINI RJ;
Indirizzi:
HARVARD UNIV,SCH MED,CONSOLIDATED DEPT PSYCHIAT BOSTON MA 00000 HARVARD UNIV,SCH MED,PROGRAM NEUROSCI BOSTON MA 00000 MASSACHUSETTS GEN HOSP,MAILMAN RES CTR,MCLEAN DIV BELMONT MA 02178
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 83, anno: 1998,
pagine: 169 - 176
SICI:
0306-4522(1998)83:1<169:LODSIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE AUTORADIOGRAPHY; CAUDATE-PUTAMEN; ANTAGONIST LIGAND; PRIMATE BRAIN; HIGH-AFFINITY; D2 RECEPTORS; D4 RECEPTORS; KAINIC ACID; EXPRESSION; NEURONS;
Keywords:
AUTORADIOGRAPHY; CORPUS STRIATUM; CEREBRAL CORTEX; DOPAMINE RECEPTORS; KAINIC ACID; NUCLEUS ACCUMBENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
F.I. Tarazi et al., "LOCALIZATION OF DOPAMINE-RECEPTOR SUBTYPES IN CORPUS STRIATUM AND NUCLEUS-ACCUMBENS-SEPTI OF RAT-BRAIN - COMPARISON OF D-1-LIKE, D-2-LIKE, AND D-4-LIKE RECEPTORS", Neuroscience, 83(1), 1998, pp. 169-176

Abstract

Changes in D-1-, D-2- and D-4-like dopamine receptor binding in rat brain were examined by quantitative autoradiography following: (i) unilateral surgical ablation of frontal cerebral cortex to remove descending projections to corpus striatum and nucleus accumbens, (ii) unilateral injections of kainic acid into corpus striatum or nucleus accumbensto degenerate local intrinsic neurons, (iii) unilateral injections of6-hydroxydopamine into substantia nigra to degenerate ascending dopamine projections. Rats were killed one week after lesioning, with contralateral tissue controls. Radioligands were: [H-3]SCH-23390 for D-1-like (D-1/D-5) receptors, [H-3]nemonapride alone for D-2-like (D-2/D-3/D-4) receptors, and [H-3]nemonapride with 300 nM S[-]-raclopride and other masking agents for D-4-like receptors (identified by blockade withD-4 selective L-745,870). Frontal cerebral cortex ablation did not alter D-1- or D-2-like receptor density, but D-4-like binding decreased significantly in both corpus striatum (18%) and nucleus accumbens (23%). Kainic acid markedly reduced D-1-like (75% and 84%) and D-2-like binding (44% and 52%), with smaller D-4-like losses (28% and 27%) in corpus striatum and nucleus accumbens, respectively. Nigral 6-hydroxydopamine lesions (verified by autoradiographic loss of dopamine transporters labelled with [H-3]GBR-12935) did not significantly change D-1-, D-2-, or D-4-like binding in the corpus striatum. These results suggest that the majority of D-1-, and D-2-like, and a smaller portion of D-4-like receptors in corpus striatum and nucleus accumbens arise on intrinsic postsynaptic neurons, and that some D-4-like, but neither D-1-norD-2-like, receptors are found on presynaptic corticostriatal afferents. (C) 1997 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 26/01/20 alle ore 00:46:15