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Titolo:
ADHERENCE OF STAPHYLOCOCCI TO VARIOUS INT RAOCULAR LENSES WITH DIFFERENT LEVELS OF HYDROPHOBICITY
Autore:
SCHLORICKE E; SCHMIDT H; SCHULZE HA; BECK R; GUTHOFF R; FALKENHAGEN U;
Indirizzi:
UNIV ROSTOCK,INST MED MIKROBIOL,SCHILLINGALLEE 70 D-18057 ROSTOCK GERMANY UNIV ROSTOCK,INST MED MIKROBIOL D-18057 ROSTOCK GERMANY UNIV ROSTOCK,EXPT FORSCHUNGSZENTRUM D-18057 ROSTOCK GERMANY UNIV ROSTOCK,AUGENKLIN D-18057 ROSTOCK GERMANY
Titolo Testata:
Der Ophthalmologe
fascicolo: 11, volume: 94, anno: 1997,
pagine: 785 - 790
SICI:
0941-293X(1997)94:11<785:AOSTVI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
GER
Soggetto:
ADHESION; EPIDERMIDIS; POLYSTYRENE; ATTACHMENT;
Keywords:
INTRAOCULAR LENSES; SURFACE MODIFICATION; HYDROPHOBICITY; STAPHYLOCOCCUS EPIDERMIDIS; BACTERIAL ATTACHMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Schloricke et al., "ADHERENCE OF STAPHYLOCOCCI TO VARIOUS INT RAOCULAR LENSES WITH DIFFERENT LEVELS OF HYDROPHOBICITY", Der Ophthalmologe, 94(11), 1997, pp. 785-790

Abstract

Background: A major goal in research on intraocular lenses (101) is the development of new polymers and modifications to reduce foreign-body reactions after implantation. This effect may be achieved by a reduction in the surface hydrophobicity of the polymers. To illustrate the influence of surface modifications on bacterial adhesiveness, the mostoften isolated organism in ''low-grade'' postoperative endophthalmitis, Staphylococcus epidermidis, was used. Materials and methods: For this reason three strains of this species, the type strain ATCC 14990 and two clinical isolates (8687, 6579 1) with different hydrophobic surface properties were studied. 101, used in the ex periments were eithermade of PMMA or silicone with modified surfaces (unpolished, polished, heparinized). The adhesiveness of H-3-thymidin-labeled bacteria was calculated/mm(2) of lens surface. Each experiment was performed in triplicate and repeated three times. Results: The hydrophobic-type strainshowed stronger adherence to unpolished PMMA surface (8000 bacteria per mm(2)) compared to the polished (5200 bacteria/mm(2)). In contrast,the hydrophilic strain adhered with 2000 bacteria/mm(2) to the unpolished and with 4200 bacteria/mm(2) to the polished surface. Polishing PMMA lenses diminished the differences between the three strains. However, surface passivation of silicone lenses increased the adhesion rateof the hydrophilic strain up to 9600 bacteria/mm(2). Treatment of PMMA lenses with heparin increased the adhesiveness of the hydrophilic strain and reduced the adhesion rate of the hydrophobic type strain to 250 bacteria/mm(2). Conclusions: It was demonstrated that bacterial adherence to IOL also involves hydrophobic interactions. Obviously, however, that adherence reflects a complex of interactions between the two surfaces.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:08:33