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Titolo:
ORPHANIN FQ ACTS AS AN ANXIOLYTIC TO ATTENUATE BEHAVIORAL-RESPONSES TO STRESS
Autore:
JENCK F; MOREAU JL; MARTIN JR; KILPATRICK GJ; REINSCHEID RK; MONSMA FJ; NOTHACKER HP; CIVELLI O;
Indirizzi:
UNIV CALIF IRVINE,COLL MED,DEPT PHARMACOL IRVINE CA 92697 UNIV CALIF IRVINE,COLL MED,DEPT PHARMACOL IRVINE CA 92697 ROCHE CNS RES,DIV PHARMA CH-4070 BASEL SWITZERLAND UNIV HAMBURG,HOSP EPPENDORF,INST CELL BIOCHEM & CLIN NEUROBIOL D-20246 HAMBURG GERMANY SCHERING PLOUGH CORP,RES INST KENILWORTH NJ 07033
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 26, volume: 94, anno: 1997,
pagine: 14854 - 14858
SICI:
0027-8424(1997)94:26<14854:OFAAAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE FAMILY; CORTICOTROPIN-RELEASING FACTOR; PROTEIN-COUPLED RECEPTOR; ELEVATED PLUS-MAZE; TISSUE DISTRIBUTION; MOLECULAR-CLONING; NEUROPEPTIDE-Y; CDNA CLONING; MEMBER; LOCALIZATION;
Keywords:
ANXIETY; BENZODIAZEPINE; NEUROPEPTIDE; PLUS MAZE; OPERANT CONFLICT;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
F. Jenck et al., "ORPHANIN FQ ACTS AS AN ANXIOLYTIC TO ATTENUATE BEHAVIORAL-RESPONSES TO STRESS", Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14854-14858

Abstract

Orphanin FQ (OFQ, Nociceptin) is a recently discovered 17-amino acid neuropeptide that is structurally related to the opioid peptides but does not bind opioid receptors. OFQ has been proposed to act as an anti-opioid peptide, but its widespread sites of action in the brain suggest that it may have more general functions. Here we show that OFQ plays an important role in higher brain functions because it can act as ananxiolytic to attenuate the behavioral inhibition of animals acutely exposed to stressful/anxiogenic environmental conditions. OFQ anxiolytic-like effects were consistent across several behavioral paradigms generating different types of anxiety states in animals (light-dark preference, elevated plus-maze, exploratory behavior of an unfamiliar environment, pharmacological anxiogenesis, operant conflict) and were observed at low nonsedating doses (0.1-3 nmol, intracerebroventricular). Like conventional anxiolytics, OFQ interfered with regular sensorimotorfunction at high doses (>3 nmol). Our results show that an important role of OFQ is to act as an endogenous regulator of acute anxiety responses. OFQ, probably in concert with other major neuropeptides, exertsa modulatory role on the central integration of stressful stimuli and, thereby, may modulate anxiety states generated by acute stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:01:53