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Titolo:
TARGETED GENE DELETION OF HEME OXYGENASE-2 REVEALS NEURAL ROLE FOR CARBON-MONOXIDE
Autore:
ZAKHARY R; POSS KD; JAFFREY SR; FERRIS CD; TONEGAWA S; SNYDER SH;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,725 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 MIT,CTR CANC RES,HOWARD HUGHES MED INST,CTR LEARNING & MEMORY CAMBRIDGE MA 02139 MIT,DEPT BIOL CAMBRIDGE MA 02139 JOHNS HOPKINS UNIV,SCH MED,DIV GASTROENTEROL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DIV PHARMACOL & MOL SCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DIV PSYCHIAT & BEHAV SCI BALTIMORE MD 21205
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 26, volume: 94, anno: 1997,
pagine: 14848 - 14853
SICI:
0027-8424(1997)94:26<14848:TGDOHO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NITRIC-OXIDE SYNTHASE; GUANYLATE-CYCLASE ACTIVATION; CYCLIC-GMP; IN-VIVO; INHIBITION; RELAXATION; MESSENGER; METALLOPORPHYRINS; MICE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Zakhary et al., "TARGETED GENE DELETION OF HEME OXYGENASE-2 REVEALS NEURAL ROLE FOR CARBON-MONOXIDE", Proceedings of the National Academy of Sciences of the United Statesof America, 94(26), 1997, pp. 14848-14853

Abstract

Neuronal nitric oxide synthase (nNOS) generates NO in neurons, and heme-oxygenase-2 (HO-2) synthesizes carbon monoxide (GO). We have evaluated the roles of NO and CO in intestinal neurotransmission using mice with targeted deletions of nNOS or HO-2, Immunohistochemical analysis demonstrated colocalization of nNOS and HO-2 in myenteric ganglia, Nonadrenergic noncholinergic relaxation and cyclic guanosine 3',5' monophosphate elevations evoked by electrical field stimulation were diminished markedly in both nNOS(Delta/Delta) and HO-2(Delta/Delta) mice, In wild-type mice, NOS inhibitors and HO inhibitors partially inhibited nonadrenergic noncholinergic relaxation. In nNOS(Delta/Delta) animals, NOS inhibitors selectively lost their efficacy, and HO inhibitors wereinactive in HO-2(Delta/Delta) animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:35:53