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Titolo:
D-2 DOPAMINE-RECEPTOR POLYMORPHISM AND BRAIN REGIONAL GLUCOSE-METABOLISM
Autore:
NOBLE EP; GOTTSCHALK LA; FALLON JH; RITCHIE TL; WU JC;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BIOBEHAV SCI LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,INST BRAIN RES LOS ANGELES CA 90024 UNIV CALIF IRVINE,DEPT PSYCHIAT & HUMAN BEHAV IRVINE CA 92717 UNIV CALIF IRVINE,DEPT ANAT IRVINE CA 92717 UNIV CALIF IRVINE,DEPT NEUROBIOL IRVINE CA 92717 UNIV CALIF IRVINE,IRVINE BRAIN IMAGING CTR IRVINE CA 92717
Titolo Testata:
American journal of medical genetics
fascicolo: 2, volume: 74, anno: 1997,
pagine: 162 - 166
SICI:
0148-7299(1997)74:2<162:DDPABR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE ABUSERS; A1 ALLELE; GENE; ASSOCIATION; ALCOHOLICS; CHILDREN; BINDING; CORTEX; RFLP;
Keywords:
D-2 DOPAMINE RECEPTOR GENE; POLYMORPHISM; BRAIN GLUCOSE METABOLISM; A1(+) AND A1(-) ALLELE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Noble et al., "D-2 DOPAMINE-RECEPTOR POLYMORPHISM AND BRAIN REGIONAL GLUCOSE-METABOLISM", American journal of medical genetics, 74(2), 1997, pp. 162-166

Abstract

Positron emission tomography (PET) studies have shown decreased glucose metabolism in brain regions of detoxified alcoholics and cocaine abusers, However, it is not clear whether this decrease is due to chronic drug abuse or a pre-existing condition, Molecular genetic studies have found an association of the D-2 dopamine receptor (DRD2) A1 allele with alcoholism and drug abuse, Moreover, reduced central dopaminergicfunction has been suggested in subjects who carry the A1 allele (A1(+)) compared with those who do not (A1(-)), In the present study, usingF-18- deoxyglucose, regional glucose metabolism was determined in healthy nonalcohol/nondrug-abusing subjects with the A1(+) or A1(-) allele, The mean relative glucose metabolic rate (GMR) was significantly lower in the A1(+) than the A1(-) group in many brain regions, includingthe putamen, nucleus accumbens, frontal and temporal gyri and medial prefrontal, occipito-temporal and orbital cortices, Decreased relativeGMR in the A1(+) group was also found in Broca's area, anterior insula, hippocampus, and substantia nigra, A few brain areas, however, showed increased relative GMR in the A1(+) group, Since polymorphism of the DRD2 gene is commonly observed in humans, the importance of differentiating A1(+) and A1(-) alleles subjects in PET studies is suggested, (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:05:53