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Titolo:
TYROSINE KINASE INHIBITORS IMPAIR LONG-TERM-MEMORY FORMATION IN DAY-OLD CHICKS
Autore:
WHITECHURCH RA; NG KT; SEDMAN GL;
Indirizzi:
MONASH UNIV,DEPT PSYCHOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT PSYCHOL CLAYTON VIC 3168 AUSTRALIA LA TROBE UNIV,SCH PSYCHOL BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Cognitive brain research
fascicolo: 2, volume: 6, anno: 1997,
pagine: 115 - 120
SICI:
0926-6410(1997)6:2<115:TKIILF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASES; SYNAPTIC TRANSMISSION; GLUTAMATE RECEPTORS; POTENTIATION; PHOSPHORYLATION; NMDA; HIPPOCAMPUS; MODEL; BRAIN; NEUROTROPHINS;
Keywords:
DAY-OLD CHICKS; PASSIVE AVOIDANCE LEARNING; TYROSINE KINASE; GENISTEIN; LAVENDUSTIN A;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Whitechurch et al., "TYROSINE KINASE INHIBITORS IMPAIR LONG-TERM-MEMORY FORMATION IN DAY-OLD CHICKS", Cognitive brain research, 6(2), 1997, pp. 115-120

Abstract

The involvement of protein kinases in numerous neuronal cellular processes, including learning and memory, has been well established, particularly regarding serine/threonine kinases. In the present study, the role of protein kinases in learning was further examined through an investigation of the effects of inhibitors of tyrosine kinase activity on memory formation. The present findings reveal that the intracranial administration of the tyrosine kinase inhibitors genistein and lavendustin A produced retention deficits in day-old chicks trained on a single-trial passive avoidance task. These deficits were not apparent until 90 min after the training episode and were not observed at all in chicks administered control substances. The possibility that the tyrosine phosphorylation disrupted by the presence of the inhibitors is related to NMDA glutamate receptor activation is considered. (C) 1997 Elsevier Science B.V.

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Documento generato il 01/04/20 alle ore 01:37:43