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Titolo:
MYOCARDIAL DAMAGE DOES NOT OCCUR IN UNTREATED HYPERTHYROIDISM UNLESS ASSOCIATED WITH CONGESTIVE-HEART-FAILURE
Autore:
MARTI V; BALLESTER M; RIGLA M; NARULA J; BERNA L; PONSLLADO G; CARRIO I; CARRERAS F; WEBB SM;
Indirizzi:
HOSP SANTA CRUZ & SAN PABLO,DEPT CARDIOL,SERV ENDOCRINOL,SANT ANTONI M CLARET 167 BARCELONA 08025 SPAIN HOSP SANTA CRUZ & SAN PABLO,DEPT CARDIOL,NUCL MED SERV BARCELONA 08025 SPAIN ALLEGHENY UNIV HLTH SCI,CARDIAC UNIT PHILADELPHIA PA 19102
Titolo Testata:
The American heart journal
fascicolo: 6, volume: 134, anno: 1997,
pagine: 1133 - 1137
SICI:
0002-8703(1997)134:6<1133:MDDNOI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSIBLE DILATED CARDIOMYOPATHY; ANTIMYOSIN ANTIBODY UPTAKE; LEFT-VENTRICULAR FUNCTION; ECHOCARDIOGRAPHIC DETERMINATION; THYROTOXICOSIS; COMPLICATIONS; VALIDATION; REJECTION; INJURY; MYOSIN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
V. Marti et al., "MYOCARDIAL DAMAGE DOES NOT OCCUR IN UNTREATED HYPERTHYROIDISM UNLESS ASSOCIATED WITH CONGESTIVE-HEART-FAILURE", The American heart journal, 134(6), 1997, pp. 1133-1137

Abstract

Even in the absence of underlying cardiac disease, hyperthyroidism has seldom been reported to be associated with left ventricular dysfunction and congestive heart failure. The left ventricular function invariably improves with achievement of euthyroid status. Anecdotal autopsy reports have suggested that myocardial necrosis associated with hyperthyroidism may be responsible for congestive heart failure. This study prospectively evaluates the role of myocardial necrosis in untreated hyperthyroidism by imaging with Indium-111 antimyosin antibody. Thirteen consecutive patients (7 men and 6 women, mean age 36 +/- 11 years) with hyperthyroidism and Graves' disease (10 patients), subacute thyroiditis (2 patients), or multinodular goiter (1 patient) formed the basis of the study. The T4 levels ranged from 33 to 183 pmol/L (mean 103 +/- 47 pmol/L) and cardiac output from 5.47 to 11.0 L/min (mean 717 +/-1.75 L/min). Two patients had clinical congestive heart failure and mildly depressed left ventricular ejection Fraction. Both patients had scintigraphic evidence of myocardial damage with abnormal antimyosin scans. In the remaining 11 patients with normal left ventricular ejection fraction, no antimyosin uptake was observed. The reevaluation of two patients with abnormal initial scans 6 to 8 months after treatment revealed euthyroid status, resolution of antimyosin uptake, and normalization of left ventricular function. This study indicates that myocardial necrosis may be detected in a smell proportion of patients with hyperthyroidism. which could contribute to left ventricular systolic dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:47:49