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Titolo:
ENZYMATIC N-RIBOSIDE SCISSION IN RNA AND RNA PRECURSORS
Autore:
SCHRAMM VL;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT BIOCHEM,1300 MORRIS PK AVEBRONX NY 10461
Titolo Testata:
CURRENT OPINION IN CHEMICAL BIOLOGY
fascicolo: 3, volume: 1, anno: 1997,
pagine: 323 - 331
SICI:
1367-5931(1997)1:3<323:ENSIRA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURINE NUCLEOSIDE PHOSPHORYLASE; RICIN-A-CHAIN; TRANSITION-STATE INHIBITORS; ELECTROSTATIC POTENTIAL SURFACE; ACTIVE-SITE; CRITHIDIA-FASCICULATA; AMP NUCLEOSIDASE; CRYSTAL-STRUCTURE; GUANINE TRANSGLYCOSYLASE; FORMYCIN 5'-PHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
V.L. Schramm, "ENZYMATIC N-RIBOSIDE SCISSION IN RNA AND RNA PRECURSORS", CURRENT OPINION IN CHEMICAL BIOLOGY, 1(3), 1997, pp. 323-331

Abstract

N-ribohydrolases and transferases act on nucleosides, nucleotides andoligonucleotides to effect base removal. Advances in mechanistic and structural analysis have established that enzymes of N-riboside scission act by combinations of leaving-group and ribosyl activation. Alternative O-riboside substrates have been developed for mechanistic diagnosis, Transition-state structures have been determined, and powerful inhibitors have been designed from structural and transition-state information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:01:44