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Titolo:
SYNAPTIC REFRACTORY PERIOD PROVIDES A MEASURE OF PROBABILITY OF RELEASE IN THE HIPPOCAMPUS
Autore:
HJELMSTAD GO; NICOLL RA; MALENKA RC;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,GRAD PROGRAM NEUROSCI SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MOL & CELLULAR PHARMACOL SAN FRANCISCO CA 94143
Titolo Testata:
Neuron
fascicolo: 6, volume: 19, anno: 1997,
pagine: 1309 - 1318
SICI:
0896-6273(1997)19:6<1309:SRPPAM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PAIRED-PULSE FACILITATION; EXCITATORY POSTSYNAPTIC CURRENTS; TRANSMITTER RELEASE; CA1 REGION; CENTRAL SYNAPSES; RAT HIPPOCAMPUS; PYRAMIDAL CELLS; TRANSMISSION; GLUTAMATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
G.O. Hjelmstad et al., "SYNAPTIC REFRACTORY PERIOD PROVIDES A MEASURE OF PROBABILITY OF RELEASE IN THE HIPPOCAMPUS", Neuron, 19(6), 1997, pp. 1309-1318

Abstract

Despite extensive research, much controversy remains regarding the locus of expression of long-term potentiation (LTP) in area CA1 of the hippocampus, specifically, whether LTP is accompanied by an increase inthe probability of release (p(r)) of synaptic vesicles. We have developed a novel method for assaying p(r) which utilizes the synaptic refractory period-a brief 5-6 ms period following release during which thesynapse is incapable of transmission (Stevens and Wang, 1995). We show that this assay is sensitive to a battery of manipulations that affect p(r) but find no change following either NMDA receptor-dependent LTP or long-term depression (LTD).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:02:34