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Titolo:
HYPOTENSIVE EFFECT OF CHRONICALLY INFUSED ADRENOMEDULLIN IN CONSCIOUSWISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
KHAN AI; KATO J; KITAMURA K; KANGAWA K; ETO T;
Indirizzi:
MIYAZAKI MED COLL,DEPT INTERNAL MED 1 MIYAZAKI 88916 JAPAN MIYAZAKI MED COLL,DEPT INTERNAL MED 1 MIYAZAKI 88916 JAPAN NATL CARDIOVASC CTR,RES INST SUITA OSAKA 565 JAPAN
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 2, volume: 24, anno: 1997,
pagine: 139 - 142
SICI:
0305-1870(1997)24:2<139:HEOCIA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE ADRENOMEDULLIN; PLASMA; PEPTIDE; TISSUE;
Keywords:
ADRENOMEDULLIN; CHRONIC INFUSION; HYPOTENSIVE EFFECT; PLASMA RENIN ACTIVITY; RAT; VASODILATATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Khan et al., "HYPOTENSIVE EFFECT OF CHRONICALLY INFUSED ADRENOMEDULLIN IN CONSCIOUSWISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS", Clinical and experimental pharmacology and physiology, 24(2), 1997, pp. 139-142

Abstract

1. The hypotensive effect of chronically infused human adrenomedullin(hAM), a potent vasodilator peptide that has been reported to have a natriuretic action, was examined in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). 2. Conscious WKY rats and SHR were infused with 200 ng/h synthetic hAM for 14 days by means ofosmotic minipumps. Control groups were infused at the same schedule with 0.9% saline. Systolic blood pressure (SBP) and daily urinary excretion of Na+ and K+ were measured before and during the infusion period. In addition, plasma renin activity (PRA), aldosterone and hAM concentrations were measured on day 14 of infusion. 3. A significant reduction in SBP was observed in hAM-treated SHR at day 2 and SBP remained significantly lower throughout the experiment compared with control SHR. Similarly, SBP in the hAM-treated WKY rats was found to be significantly lower than in control WKY rats during infusion. However, the hypotensive effect was not accompanied by any significant increase in urinary volume or Na+ excretion in hAM-treated rats of either strain. Chronic infusion with hAM significantly suppressed PRA and lowered the concentration of plasma aldosterone in WKY rats but not in SHR. The plasmahAM levels in treated WKY rats and SHR were 0.9 +/- 0.4 and 0.6 +/- 0.2 fmol/mL, respectively. 4. These findings demonstrate that chronically infused hAM has a hypotensive effect in both WKY rats and SHR without an increase in urinary volume or Na+ excretion at a plasma AM concentration within the physiological limit.

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Documento generato il 13/07/20 alle ore 17:49:34