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Titolo:
POSTTRANSPLANT HYPERLIPIDEMIA - LOW-DOSE LOVASTATIN LOWERS ATHEROGENIC LIPIDS WITHOUT PLASMA ACCUMULATION OF LOVASTATIN
Autore:
GULLESTAD L; NORDAL KP; FORFANG K; IHLEN H; HOSTMARK A; BERG KJ; CHENG H; SCHWARTZ MS; GEIRAN O; SIMONSEN S;
Indirizzi:
UNIV OSLO,RIKSHOSP,MEDISINSKAVDELING B N-0027 OSLO NORWAY UNIV OSLO,DEPT PREVENT MED OSLO NORWAY UNIV HOSP,RIKSHOSP,DEPT MED & SURG OSLO NORWAY MERCK RES LABS,DEPT DRUG METAB W POINT PA 00000
Titolo Testata:
Journal of internal medicine
fascicolo: 6, volume: 242, anno: 1997,
pagine: 483 - 490
SICI:
0954-6820(1997)242:6<483:PH-LLL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CARDIAC TRANSPLANTATION; CARDIOVASCULAR-DISEASE; HEART-TRANSPLANTATION; RECEIVING LOVASTATIN; RISK-FACTORS; HUMAN-LIVER; RECIPIENTS; HYPERCHOLESTEROLEMIA; CHOLESTEROL;
Keywords:
APOLIPOPROTEINS; CHOLESTEROL; HYPERLIPIDEMIA; LOVASTATIN; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "POSTTRANSPLANT HYPERLIPIDEMIA - LOW-DOSE LOVASTATIN LOWERS ATHEROGENIC LIPIDS WITHOUT PLASMA ACCUMULATION OF LOVASTATIN", Journal of internal medicine, 242(6), 1997, pp. 483-490

Abstract

Objectives. The purpose of the present study was twofold. First, to determine the frequency of hyperlipidaemia after heart transplantation (Tx) in relation to values obtained before Tx, Secondly, to examine the effect of low-dose lovastatin on possible antiatherogenic mechanismsand test the hypothesis that the side-effects are dose-dependent. Subjects and design. Retrospective study of the frequency of hyperlipidaemia disturbances in heart transplant patients. In addition, in a prospective study, the safety and efficacy of incremental low doses of lovastatin up to 20 mg day(-1) were studied, with measurements of its plasma concentration in 24 cyclosporin A treated heart (n = 14) and kidney(n = 10) recipients with total cholesterol >7.5 mmol L-1. Results. Cholesterol increased markedly after heart transplantation from a pretransplant value of 5.3 (5.0,5.6) mmol L-1 to 6.7 (6.4,7.0) mmolL(-1) after 1 year and then remained constant, but this increase was largely due to a 'normalization' since cholesterol decreased significantly during increasing heart failure before transplantation. Treatment with lovastatin decreased total cholesterol by 19% (P < 0.001), primarily by aneffect on LDL cholesterol. HDL cholesterol increased by 15% (P<0.05),whereas triglycerides remained unchanged. Lovastatin also caused a significant reduction in apolipoprotein B of 16%, and lipid peroxidationof 40%, whereas apolipoprotein A-I, fibrinogen, and glycerol were unchanged. Plasma concentration of lovastatin was significantly higher intransplant recipients compared with controls, but there was no accumulation during incremental dosing of lovastatin. The drug was well tolerated without significant symptoms or evidence of myopathy. Conclusions, Hyperlipidaemia is common after cardiac transplantation. Treatment with low dose lovastatin is well tolerated and has a favourable effecton atherogenic lipids.

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Documento generato il 01/12/20 alle ore 10:29:04