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Titolo:
ERYTHROCYTE AGGREGATION TENDENCY AND CELLULAR PROPERTIES IN HORSE, HUMAN, AND RAT - A COMPARATIVE-STUDY
Autore:
BASKURT OK; FARLEY RA; MEISELMAN HJ;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS,1333 SAN PABLO ST,MMR 626 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 42, anno: 1997,
pagine: 2604 - 2612
SICI:
0363-6135(1997)42:6<2604:EATACP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-BLOOD-CELLS; AQUEOUS-PHASE SYSTEMS; MEMBRANE VISCOSITY; RHEOLOGY; DEFORMABILITY; BEHAVIOR; DEXTRAN;
Keywords:
RED BLOOD CELL AGGREGATION; HEMORHEOLOGY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
O.K. Baskurt et al., "ERYTHROCYTE AGGREGATION TENDENCY AND CELLULAR PROPERTIES IN HORSE, HUMAN, AND RAT - A COMPARATIVE-STUDY", American journal of physiology. Heart and circulatory physiology, 42(6), 1997, pp. 2604-2612

Abstract

Horse blood has a higher tendency to form red blood cell (RBC) aggregates compared with human blood, with this enhanced aggregation previously attributed to differences in plasma factors. Our results confirm this observation and further indicate that washed horse RBC also have asignificantly higher aggregation tendency in dextran 70 solutions (i.e., horse RBC have a higher ''aggregability''). In contrast, the aggregation tendency of rat RBC, both in autologous plasma and in dextran 70, is significantly less compared with human and horse RBC. Other rheological findings for horse and rat RBC include smaller changes in RBC deformation indexes over the same shear stress range and a lower RBC shape recovery time constant. Rat RBC also had higher two-phase aqueouspolymer partition coefficients, suggesting a higher surface charge. Membrane protein analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed marked differences: 1) band 4.2 protein was lacking in horse RBC membranes, and 2) carbohydrate groups have different distributions in human, rat, and horse RBC, as indicated by different patterns in periodic acid-Schiff-stained protein bands. Our resultsclearly indicate significant differences in RBC aggregability among the three species and indicate that cellular factors contribute importantly to these differences. Furthermore, they suggest that systematic studies of blood and RBC from different species should provide insight into the mechanism(s) of RBC aggregation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:38:02