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Titolo:
CARCINOMA-ASSOCIATED-RETINOPATHY IN THE P RESENCE OF BREAST-CARCINOMAAND A CERVICAL CARCINOID-TUMOR
Autore:
HOLZ FG; BELLMANN C; STEFFEN H; NOLLE B; HUOBER J; KRASTEL H; ALEXANDRIDIS E;
Indirizzi:
UNIV HEIDELBERG,AUGENKLIN,NEUENHEIMER FELD 400 D-69120 HEIDELBERG GERMANY CHRISTIAN ALBRECHTS UNIV KIEL,AUGENKLIN KIEL GERMANY UNIV HEIDELBERG,FRAUENKLIN D-6900 HEIDELBERG GERMANY
Titolo Testata:
Der Ophthalmologe
fascicolo: 5, volume: 94, anno: 1997,
pagine: 337 - 342
SICI:
0941-293X(1997)94:5<337:CITPRO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
GER
Soggetto:
CANCER-ASSOCIATED RETINOPATHY; SMALL-CELL-CARCINOMA; MELANOMA-ASSOCIATED RETINOPATHY; OCCULT OUTER RETINOPATHY; CALCIUM-BINDING PROTEIN; PARANEOPLASTIC RETINOPATHY; PHOTORECEPTOR DEGENERATION; AUTOANTIBODIES; ANTIBODIES; RECOVERIN;
Keywords:
CARCINOMA-ASSOCIATED RETINOPATHY; PARANEOPLASTIC SYNDROME; RETINAL ANTIBODIES; RECOVERIN; IMMUNOSUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F.G. Holz et al., "CARCINOMA-ASSOCIATED-RETINOPATHY IN THE P RESENCE OF BREAST-CARCINOMAAND A CERVICAL CARCINOID-TUMOR", Der Ophthalmologe, 94(5), 1997, pp. 337-342

Abstract

Background: Carcinoma-associated retinopathy (CAR) is a rare paraneoplastic syndrome characterized by diffuse retinal photoreceptor degeneration in the presence of an epithelial tumor. We report on three patients, who developed paraneoplastic retinopathy in the presence of breast carcinoma and a cervical carcinoid tumor. Materials and methods:ln addition to biomicroscopic, psychophysical, electrophysiological and angiographic examinations, serum samples were obtained for immunohistochemical staining of human retina. Results: Ring-shaped visual field defects with statokinetic dissociation and abnormal rod and cone responses were found. Immunohistochemical findings included reactions at the level of the inner segments of the photoreceptors, the outer nuclear layer and the outer plexiform layer in absence of antirecoverin antibodies. Conclusions: CAR should be considered in the differential diagnosis of visual loss in presence of tumors other than small-cell carcinomaof the lung. The presence of antiretinal antibodies is compatible with a tumor-induced immune response to epitopes shared by both the tumorand retinal tissue. Apparently, various retinal proteins may functionas autoantigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:31:54