Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE INTERACTION BETWEEN PROPRANOLOL AND THE NOVEL ANTIMIGRAINE AGENT ZOLMITRIPTAN (311C90)
Autore:
PECK RW; SEABER EJ; DIXON R; GILLOTIN CG; WEATHERLEY BC; LAYTON G; POSNER J;
Indirizzi:
GLAXO WELLCOME RES & DEV LTD,GREENFORD RD GREENFORD UB6 0HE MIDDX ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 6, volume: 44, anno: 1997,
pagine: 595 - 599
SICI:
0306-5251(1997)44:6<595:TIBPAT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; INHIBITION; METABOLISM; CLEARANCE;
Keywords:
PROPRANOLOL; ZOLMITRIPTAN; INTERACTION; MIGRAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.W. Peck et al., "THE INTERACTION BETWEEN PROPRANOLOL AND THE NOVEL ANTIMIGRAINE AGENT ZOLMITRIPTAN (311C90)", British journal of clinical pharmacology, 44(6), 1997, pp. 595-599

Abstract

Aims Zolmitriptan (Zomig, formerly known as 311C90), a selective 5HT(1B/1D) agonist is under development as an acute oral treatment for migraine, Despite the use of prophylactic medication, such as propranolol, breakthrough attacks often occur in patients. Consequently we investigated the effects of propranolol on the pharmacokinetics of and cardiovascular responses to, zolmitriptan. Methods A double-blind, randomized, crossover study of the effects of pre-treatment with propranolol 160 mg daily for 7 days or placebo on the pharmacokinetics and effects on blood pressure of a single 10 mg dose of zolmitriptan in 12 healthyvolunteers, Results Propranolol increased mean zolmitriptan C-max andAUC by 56% and 37% respectively; mean t(1/2) was prolonged from 3.1 to 4.0 h. Mean C-max and AUC of the pharmacologically active N-desmethyl metabolite were reduced by 24% and 11% respectively and the metabolite:parent AUC ratio (AUC(m)/AUC(p)) fell from 0.46 to 0.26. Mean C-maxand AUC for the inactive indole acetic acid metabolite were both reduced by 13% and AUC(m)/AUC(p) from 1.04 to 0.59. A small pressor effectof short duration was observed following zolmitriptan with mean peak rises of 13 and 11 mmHg in systolic and diastolic pressures respectively; propranolol had no effect on the presser response, Conclusions Theresults suggest that propranolol inhibits biotransformation of zolmitriptan but with no change in the small pressor response to zolmitriptan. It is therefore unlikely that the pharmacokinetic changes will leadto clinically important changes in pharmacological effects and dosageadjustment of zolmitriptan is not required in patients taking propranolol for migraine prophylaxis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:05:15