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Titolo:
INTENSITY DEPENDENCE OF THE CORTICAL AUDITORY-EVOKED POTENTIALS AS A SURROGATE MARKER OF CENTRAL-NERVOUS-SYSTEM SEROTONIN TRANSMISSION IN MAN - DEMONSTRATION OF A CENTRAL EFFECT FOR THE 5HT(1B 1D) AGONIST ZOLMITRIPTAN (311C90, ZOMIG(R))/
Autore:
PROIETTICECCHINI A; AFRA J; SCHOENEN J;
Indirizzi:
UNIV LIEGE,DEPT NEUROL,CHR CITADELLE B-4000 LIEGE BELGIUM UNIV LIEGE,DEPT NEUROL,CHR CITADELLE B-4000 LIEGE BELGIUM
Titolo Testata:
Cephalalgia
fascicolo: 8, volume: 17, anno: 1997,
pagine: 849 - 854
SICI:
0333-1024(1997)17:8<849:IDOTCA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST; TRIGEMINAL NEURONS; MIGRAINE INTERVAL; SUMATRIPTAN; BRAIN; NEUROTRANSMISSION; INHIBITION; ACTIVATION; RESPONSES; ATTACK;
Keywords:
CORTICAL AUDITORY EVOKED POTENTIAL; 5HT(1B/D) RECEPTORS; MIGRAINE; SEROTONIN; ZOLMITRIPTAN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Proietticecchini et al., "INTENSITY DEPENDENCE OF THE CORTICAL AUDITORY-EVOKED POTENTIALS AS A SURROGATE MARKER OF CENTRAL-NERVOUS-SYSTEM SEROTONIN TRANSMISSION IN MAN - DEMONSTRATION OF A CENTRAL EFFECT FOR THE 5HT(1B 1D) AGONIST ZOLMITRIPTAN (311C90, ZOMIG(R))/", Cephalalgia, 17(8), 1997, pp. 849-854

Abstract

As shown in animal studies, 5HT(1B/D) agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for theirantimigraine effect. To demonstrate a possible central nervous system(CNS) action of these compounds in man we studied their effect on theintensity dependence of the cortical auditory evoked potentials (IDAPs), thought to be inversely related to central serotonergic transmission. An amplitude/stimulus intensity function (ASF) slope was computed in healthy volunteers and migraine patients between attacks before and2 h after oral 311C90 (zolmitriptan ''Zomig'') 10 mg (n=14), 311C90 5mg (n=7), sumatriptan 100 mg (n=14), dexfenfluramine 15 mg (n=4), lorazepam 1.25 mg (n=4) and placebo (n=14). 311C90 10 mg and, to a lesserdegree, 5 mg significantly increased the mean ASF slope (p=0.007 and 0.05 vs placebo). There was a significant positive correlation betweenplasma levels of 311C90 and ASF slope changes. Sumatriptan and lorazepam had little effect, but dexfenfluramine produced a significant ASF slope decrease. 311C90 is able to modify a CNS activity that is modulated by serotonin, i.e. the IDAP. This effect is probably the consequence of its superior lipophilicity compared to sumatriptan and of activation of prejunctional 5HT(1B/D) autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices.

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Documento generato il 26/01/20 alle ore 17:04:38