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Titolo:
BRAIN IMAGING OF SCHIZOPHRENIA - THE DOPAMINE HYPOTHESIS
Autore:
FARDE L;
Indirizzi:
KAROLINSKA HOSP,PSYCHIAT CLIN S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT CLIN NEUROSCI STOCKHOLM SWEDEN
Titolo Testata:
Schizophrenia research
fascicolo: 2-3, volume: 28, anno: 1997,
pagine: 157 - 162
SICI:
0920-9964(1997)28:2-3<157:BIOS-T>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; D2-DOPAMINE RECEPTOR OCCUPANCY; C-11 N-METHYLSPIPERONE; LIVING HUMAN-BRAIN; COMPUTERIZED-TOMOGRAPHY; H-3-SPIPERONE BINDING; ANTIPSYCHOTIC-DRUGS; D-2; PET; DENSITY;
Keywords:
SCHIZOPHRENIA; DOPAMINE; D-2-DOPAMINE RECEPTORS; POSITRON EMISSION TOMOGRAPHY (PET); NEUROLEPTIC DRUGS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L. Farde, "BRAIN IMAGING OF SCHIZOPHRENIA - THE DOPAMINE HYPOTHESIS", Schizophrenia research, 28(2-3), 1997, pp. 157-162

Abstract

The dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. The two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging studies on the dopamine system. There is a high occupancy of central D-2-dopamine receptors in patients that are treated with clinically effective doses of classical antipsychotic drugs and recent studies indicate an abnormal function of the presynaptic dopaminergic neuron. Early reports of elevated postsynaptic D-2-dopamine receptors in schizophrenic brains post mop tern have, however, not been consistently confirmed by brain imaging studies of young neuroleptic-naive patients with schizophrenia. Suitable methods are now being developed for brain imaging of the dopamine system in the limbic and neocortical regions that are of central interest in schizophrenia research. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:02:29