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Titolo:
GABA(A) RECEPTOR FUNCTION IN THE CEREBRAL-CORTEX OF ALCOHOL-NAIVE P-RATS AND NP RATS
Autore:
THIELEN RJ; MCBRIDE WJ; LUMENG L; LI TK;
Indirizzi:
INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PSYCHIAT,791 UNION DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT PSYCHIAT INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT MED & BIOCHEM INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,INST PSYCHIAT RES,DEPT MOL BIOL INDIANAPOLIS IN 46202 VET ADM MED CTR INDIANAPOLIS IN 46202
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 59, anno: 1998,
pagine: 209 - 214
SICI:
0091-3057(1998)59:1<209:GRFITC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; ACTIVATED CHLORIDE CHANNELS; SHORT-SLEEP MICE; GATED ION CHANNELS; LONG-SLEEP; ETHANOL; SENSITIVITY; POTENTIATION; FLUX;
Keywords:
GABA(A) RECEPTORS; CHLORIDE INFLUX; ALCOHOL-PREFERRING RATS; PENTOBARBITAL; PHENOBARBITAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Thielen et al., "GABA(A) RECEPTOR FUNCTION IN THE CEREBRAL-CORTEX OF ALCOHOL-NAIVE P-RATS AND NP RATS", Pharmacology, biochemistry and behavior, 59(1), 1998, pp. 209-214

Abstract

Previous studies have demonstrated an innate difference in the sensitivity of ethanol-naive P and NP rats to the acute intoxicating effectsof high doses of ethanol. A number of studies have suggested that theacute intoxicating effects of ethanol may be mediated in part throughpotentiation of GABA(A)/benzodiazepine receptor function. In the present study, the function of GABA(A)/benzodiazepine receptors was studied in ethanol-naive alcohol-preferring (P) and -nonpreferring (NP) lines of rats by measuring Cl-36(-) influx into cortical microsacs. GABA, in a concentration-dependent manner, increased Cl-36(-) influx to an equivalent extent into cortical microsacs from P and NP rats (EC50 = 9.0 +/- 1.0 and 10 +/- 1.1 mu M; E-max = 30.8 +/- 1.3 and 28.1 +/- 0.9 nmol Cl-/mg protein/ 3 s, respectively). Pentobarbital (30 mu M) enhanced GABA-stimulated Cl-36(-) uptake (75 and 71% increase for P and NP rats, respectively) equally well in cortical microsacs from P and NP rats. Likewise, phenobarbital potentiation of GABA-stimulated Cl-36(-) influx was similar in cortical microsacs from P and NP rats. Phenobarbital, at the highest concentration tested (3 mM), directly stimulated Cl-36(-) influx to a similar extent in P and NP rats. However, ethanol failed to alter GABA-stimulated Cl-36(-) uptake into cortical microsacs prepared from ethanol-naive P and NP rats. The present results suggest that the differences between P and NP rats in innate sensitivity tothe high dose effects of ethanol do not appear to be due to differences in cortical GABA(A) receptor function. (C) 1998 Elsevier Science.

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Documento generato il 06/04/20 alle ore 02:12:19