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Titolo:
BLOCKADE OF THE ANXIOLYTIC ACTION OF 8-OH-DPAT IN LACTATING RATS
Autore:
FERNANDEZGUASTI A; PICAZO O; FERREIRA A;
Indirizzi:
CINVESTAV,SECC TERAPEUT EXPT,DEPT FARMACOL & TOXICOL,AP POSTAL 22026 MEXICO CITY 14000 DF MEXICO INST MEXICANO PSIQUITRIA MEXICO CITY DF MEXICO INST POLITECN NACL,ESCUELA SUPER MED MEXICO CITY DF MEXICO UNIV REPUBLICA,FAC CIENCIAS MONTEVIDEO URUGUAY UNIV REPUBLICA,FAC VET MONTEVIDEO URUGUAY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 59, anno: 1998,
pagine: 45 - 50
SICI:
0091-3057(1998)59:1<45:BOTAAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BURYING BEHAVIOR; SEROTONERGIC ANXIOLYTICS; LORDOSIS BEHAVIOR; RECEPTOR AGONIST; 5-HT1A COMPOUNDS; ESTROUS-CYCLE; ANXIETY; IPSAPIRONE; BUSPIRONE; PROLACTIN;
Keywords:
8-OH-DPAT; LACTATION; BURYING BEHAVIOR; FREEZING BEHAVIOR; ANXIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A. Fernandezguasti et al., "BLOCKADE OF THE ANXIOLYTIC ACTION OF 8-OH-DPAT IN LACTATING RATS", Pharmacology, biochemistry and behavior, 59(1), 1998, pp. 45-50

Abstract

The anxiolytic action of 8-OH-DPAT (0.125, 0.5, and 0.75 mg/kg, IP, -15 min) was evaluated in ovariectomized and 7-day lactating mother rats. This serotonergic anxiolytic produces a clear reduction in cumulative burying behavior and in freezing time (parameters denoting a reduction in anxiety levels) in ovariectomized subjects. However, in 7-day lactating mother rats, 8-OH-DPAT lacked its antianxiety effects. Additionally, as an extra parameter of the animal's emotionality the number of defecation bolus was registered. A reduction in this parameter in ovariectomized animals after 8-OH-DPAT (0.5 mg/kg) injection was found. This effect was also blocked in 7-day lactating rats. None of the doses of the compound tested altered the burying behavior latency (a parameter inversely representing the animal's reactivity). The general ambulatory behavior of ovariectomized subjects was significantly impairedat the highest dose (0.75 mg/kg) of 8-OH-DPAT. Lower doses did not alter this parameter or the number of times lines are crossed (a parameter denoting exploratory activity). Discussion is focused on the relationship between the activity of the serotonergic system and the secretion of prolactin in this period. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 16:38:51