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Titolo:
A 2-SEPARATE-MOTIVATIONAL-SYSTEMS HYPOTHESIS OF OPIOID ADDICTION
Autore:
BECHARA A; NADER K; VANDERKOOY D;
Indirizzi:
UNIV TORONTO,FAC MED,DEPT ANAT & CELL BIOL,NEUROBIOL RES GRP TORONTO ON M5S 1A8 CANADA UNIV TORONTO,FAC MED,DEPT ANAT & CELL BIOL,NEUROBIOL RES GRP TORONTO ON M5S 1A8 CANADA UNIV IOWA,COLL MED,DEPT NEUROL IOWA CITY IA 52242
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 59, anno: 1998,
pagine: 1 - 17
SICI:
0091-3057(1998)59:1<1:A2HOOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; MESENCEPHALIC LOCOMOTOR REGION; MORPHINE-DEPENDENT RATS; MESOLIMBIC DOPAMINE SYSTEM; OPIATE WITHDRAWAL SYNDROME; PHYSICAL-DEPENDENCE; HEROIN REWARD; 6-HYDROXYDOPAMINE LESIONS; DISCRIMINATIVE PROPERTIES;
Keywords:
PLACE CONDITIONING; MESOLIMBIC DOPAMINE; TEGMENTAL PEDUNCULOPONTINE NUCLEUS; MOTIVATION; WITHDRAWAL; OPIATES; ADDICTION; DRUG DEPENDENCE; REVIEW;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
139
Recensione:
Indirizzi per estratti:
Citazione:
A. Bechara et al., "A 2-SEPARATE-MOTIVATIONAL-SYSTEMS HYPOTHESIS OF OPIOID ADDICTION", Pharmacology, biochemistry and behavior, 59(1), 1998, pp. 1-17

Abstract

There has been a long debate as to whether opioids are sought for withdrawal relief or for their ability to serve as incentives in their own right. We suggest that independent motivational systems mediate the rewarding effects of opioids in the nondependent state and in the physically dependent/withdrawal state. In the opioid-dependent state and the presence of opioid withdrawal. the rewarding effects of withdrawal relief inhibit or mask the acute rewarding effects initially exerted in the nondependent state, but the acute rewarding effects are unmaskedafter the alleviation of withdrawal. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:24:33