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Titolo:
ANTAZOLINE INCREASES INSULIN-SECRETION AND IMPROVES GLUCOSE-TOLERANCEIN RATS AND DOGS
Autore:
BERDEU D; PUECH R; RIBES G; LOUBATIERESMARIANI MM; BERTRAND G;
Indirizzi:
CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,UPR 9023,RUE CARDONILLE F-34094 MONTPELLIER 5 FRANCE CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,UPR 9023 F-34094 MONTPELLIER 5 FRANCE FAC MED MONTPELLIER,PHARMACOL LAB,INST BIOL F-34060 MONTPELLIER FRANCE UMR 9921 CNRS MONTPELLIER FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 324, anno: 1997,
pagine: 233 - 239
SICI:
0014-2999(1997)324:2-3<233:AIIAIG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE K+ CHANNELS; PANCREATIC BETA-CELLS; ALPHA-2-ADRENOCEPTOR BLOCKADE; DIABETES-MELLITUS; RELEASE; STIMULATION; PHENTOLAMINE; SOMATOSTATIN; DERIVATIVES; ANTAGONIST;
Keywords:
IMIDAZOLINE; ANTAZOLINE; INSULIN SECRETION; SOMATOSTATIN SECRETION; GLUCOSE TOLERANCE; PANCREAS; (RAT); (DOG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D. Berdeu et al., "ANTAZOLINE INCREASES INSULIN-SECRETION AND IMPROVES GLUCOSE-TOLERANCEIN RATS AND DOGS", European journal of pharmacology, 324(2-3), 1997, pp. 233-239

Abstract

In vivo effects of an imidazoline devoid of alpha(2)-adrenoceptor antagonistic properties, antazoline, on insulin secretion and glycemia were investigated both in fasted rats and dogs. In both species, antazoline (1.5 mg/kg i.v.) transiently increased insulinemia without affecting basal plasma glucose levels. In contrast, during an i.v. glucose tolerance test, antazoline markedly potentiated insulin release and thusincreased the glucose disappearance rate. In rats, during an oral glucose tolerance test, the intragastric administration of antazoline (1.5 mg/kg) clearly enhanced insulin secretion and reduced hyperglycemia. In dogs provided with a venous pancreatico-duodenal bypass, antazoline (0.5 mg/kg i.v.) induced an immediate and transient increase in Insulin and somatostatin but not in glucagon pancreaticoduodenal outputs. In conclusion, intravenously and orally administered, the imidazoline antazoline is able to stimulate insulin secretion in vivo and improve glucose tolerance. The imidazoline compounds could therefore have a potential therapeutic relevance as new antihyperglycemic insulinotropic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:04:14