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Titolo:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA - LACK OF A PROGNOSTIC VALUE OF CLEAR-CELL MORPHOLOGY
Autore:
CHANG HJ; SU IJ; CHEN CL; CHIANG IP; CHEN YC; WANG CH; CHENG AL;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 10016 TAIWAN NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED TAIPEI 10016 TAIWAN NATL TAIWAN UNIV HOSP,DEPT ONCOL TAIPEI 10016 TAIWAN NATL TAIWAN UNIV HOSP,DEPT PATHOL TAIPEI 10016 TAIWAN NATL TAIWAN UNIV HOSP,DEPT LAB MED TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,CTR CANC RES TAIPEI 10764 TAIWAN
Titolo Testata:
Oncology
fascicolo: 3, volume: 54, anno: 1997,
pagine: 193 - 198
SICI:
0030-2414(1997)54:3<193:ALWD-L>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOPROLIFERATIVE DISORDERS; CHROMOSOMAL-ABNORMALITIES; LYMPHOMA; DNA; REARRANGEMENT; EXPRESSION; FEATURES; ANTIGEN;
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; DYSPROTEINEMIA; PERIPHERAL T CELL LYMPHOMA; CLEAR CELL; CONVOLUTED CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Chang et al., "ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA - LACK OF A PROGNOSTIC VALUE OF CLEAR-CELL MORPHOLOGY", Oncology, 54(3), 1997, pp. 193-198

Abstract

It has been suggested that angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is closely related to peripheral T cell lymphoma (PTCL). However, the clinical course of AILD-like PTCL is notoriously unpredictable. A minor portion of patients enjoyed prolonged remission with steroid-only treatments (indolent AILD) while most others died rapidly despite the use of intensive chemotherapy (aggressive AILD). Recently, it has been suggested that histological features such as the presence or absence of clear cells and convoluted cells are of high prognostic value. The validity of this observation was addressed in this study. Eighteen patients who presented between 1977 and 1994 at the National Taiwan University Hospital were retrospectively studied. There were 11 men and 7 women, with a median age of 47 years. Twelve patientshad received various regimens of systemic chemotherapy, and the other3 patients had been treated with steroids alone. Eight patients had indolent AILD and 6 aggressive AILD. The follow-up period in 4 patientswas too short to be analyzed. The histopathology of these cases was divided, according to the criteria of Aozasa ct al., into group I (neither cells), 4 patients; group II (only convoluted cells), 1 patient, and group III (clear cells with or without convoluted cells), 13 patients. Contrary to others, our data revealed that group III patients weredoing better than group I patients. Univariate analysis of other pertinent clinical features, including sex, age, lymphadenopathy, B symptoms, hepatosplenomegaly, hypergammaglobulinemia, elevated serum lactatedehydrogenase, and treatment regimens, revealed none of them to be prognostically relevant. However, patients who had achieved complete remission by steroids or other systemic chemotherapy had a significantly better prognosis than those who had not. Together, these preliminary data suggested that (1) the presence or absence of clear cells and convoluted cells failed to predict the clinical behavior; and (2) induction of complete remission by steroids or other chemotherapeutic agents is an important prognostic index.

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Documento generato il 30/11/20 alle ore 00:43:39