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Titolo:
ACID PRODUCTION IN CHRONIC-HEMODIALYSIS PATIENTS
Autore:
URIBARRI J; ZIA M; MAHMOOD J; MARCUS RA; OH MS;
Indirizzi:
MT SINAI MED CTR,DEPT MED,1 GUSTAVE LEVY PL NEW YORK NY 10029 SUNY HLTH SCI CTR BROOKLYN NY 11203
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 1, volume: 9, anno: 1998,
pagine: 114 - 120
SICI:
1046-6673(1998)9:1<114:APICP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC SULFATE; DIALYSIS PATIENTS; BASE-BALANCE; BICARBONATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J. Uribarri et al., "ACID PRODUCTION IN CHRONIC-HEMODIALYSIS PATIENTS", Journal of the American Society of Nephrology, 9(1), 1998, pp. 114-120

Abstract

This study examines endogenous acid production in a group of stable chronic hemodialysis patients with no residual renal function who were admitted to the chronic hemodialysis unit of Mount Sinai Hospital. Netacid production was estimated by the change in body bicarbonate content, which occurs in the interdialytic period. The body bicarbonate content at any time was measured by multiplying the concentration of blood bicarbonate by the apparent bicarbonate space at that time. The apparent bicarbonate space was determined by the change in blood bicarbonate concentration induced by the intravenous administration of a known amount of sodium bicarbonate. Daily sulfuric acid production was also estimated from the reduction in body sulfate content during dialysis. The interdialytic net acid production was measured at approximately 28mEq/d, a value much lower than that predicted from the protein catabolic rate. This reduced acid production can be explained by reduced sulfuric acid and organic acid production. The mechanism of reduced sulfuric acid production is unknown. Reduced organic acid production is explained partly by the absence of renal excretion of metabolizable organic anions, leaving only the nonmetabolizable fraction as the main source of acid in the interdialytic period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:25:14