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Titolo:
DOPAMINE UPTAKE SITES, LABELED WITH [H-3]GBR12935, IN BRAIN SAMPLES FROM DEPRESSED SUICIDES AND CONTROLS
Autore:
BOWDEN C; CHEETHAM SC; LOWTHER S; KATONA CLE; CROMPTON MR; HORTON RW;
Indirizzi:
NOVO NORDISK AS,PHARMACEUT CRAWLEY RH11 9RT W SUSSEX ENGLAND ST GEORGE HOSP,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL LONDON SW17 0RE ENGLAND KNOLL PHARMACEUT RES & DEV NOTTINGHAM NG1 1GF ENGLAND UNIV COLL LONDON,SCH MED,DEPT PSYCHIAT LONDON W1N 8AA ENGLAND ST GEORGE HOSP,SCH MED,DEPT FORENS MED LONDON SW17 0RE ENGLAND
Titolo Testata:
European neuropsychopharmacology
fascicolo: 4, volume: 7, anno: 1997,
pagine: 247 - 252
SICI:
0924-977X(1997)7:4<247:DUSLW[>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 GBR-12935 BINDING; CEREBROSPINAL-FLUID MONOAMINE; 5-HT UPTAKE SITES; PARKINSONS-DISEASE; AMINE METABOLITES; )H-3>GBR-12935 BINDING; AFFECTIVE-DISORDERS; PREFRONTAL CORTEX; POST-MORTEM; SCHIZOPHRENIA;
Keywords:
DOPAMINE UPTAKE SITES; [H-3]GBR12935 BINDING; BASAL GANGLIA; SUICIDE; DEPRESSION; POSTMORTEM BRAIN TISSUE; ANTIDEPRESSANT DRUG;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C. Bowden et al., "DOPAMINE UPTAKE SITES, LABELED WITH [H-3]GBR12935, IN BRAIN SAMPLES FROM DEPRESSED SUICIDES AND CONTROLS", European neuropsychopharmacology, 7(4), 1997, pp. 247-252

Abstract

We have quantitated dopamine uptake sites, labelled with [H-3]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and those in whom prescription of antidepressant drugs was clearly documented. We found no significant differences between controls and suicides overall, or when the suicides were divided on the basis of antidepressant treatment or violence of death. A significant negative correlation between the number of dopamine uptake sites and age was found in each region studied. Our results suggest dopamine uptake sites are not critically involved in depressionor antidepressant drug action. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:35:20