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Titolo:
IMMUNOGLOBULIN ISOTYPES IN THE VITREOUS O F HORSES WITH AND WITHOUT RECURRENT UVEITIS
Autore:
WAGNER B; BRANDT K; SHEORAN A; HOLMES MA; DEEGEN E; LEIBOLD W;
Indirizzi:
TIERARZTLICHEN HSCH HANNOVER,KLIN PFERDE,BISCHOFSHOLER DAMM 15 D-30173 HANNOVER GERMANY TIERARZTLICHEN HSCH HANNOVER,KLIN PFERDE D-30173 HANNOVER GERMANY TIERARZTLICHEN HSCH HANNOVER,ARBEITSGRP IMMUNOL D-30173 HANNOVER GERMANY UNIV CAMBRIDGE,DEPT CLIN VET MED CAMBRIDGE CB3 0ES ENGLAND
Titolo Testata:
DTW. Deutsche tierarztliche Wochenschrift
fascicolo: 11, volume: 104, anno: 1997,
pagine: 467 - 470
SICI:
0341-6593(1997)104:11<467:IIITVO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
GER
Soggetto:
LEPTOSPIRA-INTERROGANS; EQUINE; ANTIBODIES; INFECTION; CORNEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Wagner et al., "IMMUNOGLOBULIN ISOTYPES IN THE VITREOUS O F HORSES WITH AND WITHOUT RECURRENT UVEITIS", DTW. Deutsche tierarztliche Wochenschrift, 104(11), 1997, pp. 467-470

Abstract

The functional properties of different immunoglobulin isotypes in equine recurrent uveitis (ERU) has not been investigated yet. Here, we describe the quantitative determination of total immunoglobulin levels and isotyp differentiation in the vitreous of four horses with ERU as compared to that of seven healthy horses. In contrast to almost equal amounts of total immunoglobulin in the vitreous of both groups, remarkable differences were round: All four of the horses with ERU had significantly higher IgA contents in their Vitreous as compared to the control group. However, the other isotypes monitored (IgM, IgGa, IgGb, IgGcand IgG(T)) indicated no differences between both groups. Comparing the individual ratios of immunoglobulin isotypes in the vitreous and the autologous serum of two horses with ERU and two control animals provided informative results: IgM was only detected in serum but not at all in Vitreous of all horses investigated. All four IgG isotypes monitored in the diseased animals as well as these IgG isotypes and the IgA in healthy animals were present in the same ratios in serum and in vitreous of the individual horses. In general, the content of such isotypes in the Vitreous was about 1000 fold lower then the respective isotypes in the autologous serum. These results are compatible with a transfer of the IgG and IgA isotypes from the serum into the Vitreous in healthy individuals. All four horses with ERU, however, had a selectively increased relative IgA content in the vitreous as compared to their serum. This argues for a preferential local IgA production within the framework of a local immunological reaction to antigens located withinthe eyes of horses with ERU.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:37:57