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Titolo:
NUMBERS, TIME AND NEOCORTICAL NEURONOGENESIS - A GENERAL DEVELOPMENTAL AND EVOLUTIONARY MODEL
Autore:
CAVINESS VS; TAKAHASHI T; NOWAKOWSKI RS;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL BOSTON MA 02114 KEIO UNIV,SCH MED,DEPT PEDIAT TOKYO 160 JAPAN UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL PISCATAWAY NJ 08854
Titolo Testata:
Trends in neurosciences
fascicolo: 9, volume: 18, anno: 1995,
pagine: 379 - 383
SICI:
0166-2236(1995)18:9<379:NTANN->2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-CORTEX; VISUAL-CORTEX; STEM-CELLS; MAMMALS; NEURONS; BRAIN; MOUSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
V.S. Caviness et al., "NUMBERS, TIME AND NEOCORTICAL NEURONOGENESIS - A GENERAL DEVELOPMENTAL AND EVOLUTIONARY MODEL", Trends in neurosciences, 18(9), 1995, pp. 379-383

Abstract

The number of neurons in the neocortex is the product of the size of the preneuronogenetic founder population, that is, the number of proliferative cells that are present at the onset of neuronogenesis, and neuronogenetic amplification occurring as neurons are being produced. The amount of neuronogenetic amplification is determined by changes in the output fraction, Q, from 0 to 1, over a fixed number of cell cycles, Greater neuronogenetic amplification would occur across species if the number of cell cycles during which Q < 0.5 increased. Since neitherthe length of the cell cycle nor the length of the neuronogenetic interval, that is, time per se, influence neuron number directly it is speculated that changes in these parameters are essential to neuronal diversity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:00:43