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Titolo:
HYPERGLYCEMIA RATHER THAN INSULIN-RESISTANCE IS RELATED TO REDUCED CORONARY FLOW RESERVE IN NIDDM
Autore:
YOKOYAMA I; OHTAKE T; MOMOMURA S; YONEKURA K; WOOSOO S; NISHIKAWA J; SASAKI Y; OMATA M;
Indirizzi:
UNIV TOKYO,DEPT INTERNAL MED 2,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,DEPT RADIOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Diabetes
fascicolo: 1, volume: 47, anno: 1998,
pagine: 119 - 124
SICI:
0012-1797(1998)47:1<119:HRTIIR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; DEPENDENT DIABETES-MELLITUS; ARTERY DISEASE; HEART-DISEASE; N-13 AMMONIA; PATHOLOGICAL SPECTRUM; CAROTID-ARTERY; SYNDROME-X; HYPERINSULINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
I. Yokoyama et al., "HYPERGLYCEMIA RATHER THAN INSULIN-RESISTANCE IS RELATED TO REDUCED CORONARY FLOW RESERVE IN NIDDM", Diabetes, 47(1), 1998, pp. 119-124

Abstract

To clarify if coronary flow reserve (CFR) is related to insulin resistance or hyperglycemia in normotensive NIDDM, myocardial blood flow (MBF) at baseline and during dipyridamole loading were measured with N-13-ammonia positron-emission tomography. CFR was significantly reduced in NIDDM patients compared with age-matched control subjects. CFR in patients with well-controlled NIDDM was significantly higher than in those with poorly controlled NIDDM, whereas insulin resistance was comparable between the two groups, CFR in NIDDM patients was not related tothe degree of insulin resistance. CFR correlated significantly with average fasting glucose concentration and average HbA(1c), but not withinsulin resistance, age, lipid parameters, or blood pressure. In conclusion, control of blood glucose concentration rather than insulin resistance is most likely related to the reduced CFR in NIDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:04:26