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Titolo:
TRANSCRIPTIONAL REGULATION OF SODIUM-TRANSPORT BY VASOPRESSIN IN RENAL-CELLS
Autore:
DJELIDI S; FAY M; CLUZEAUD F; ESCOUBET B; EUGENE E; CAPURRO C; BONVALET JP; FARMAN N; BLOTCHABAUD M;
Indirizzi:
UNIV PARIS 07,INST FEDERATIF RECH CELLULES EPITHELIALES,INSERM,U246,16 RUE HENRI HUCHARD F-75870 PARIS 18 FRANCE UNIV PARIS 07,INST FEDERATIF RECH CELLULES EPITHELIALES,INSERM,U246 F-75870 PARIS 18 FRANCE UNIV PARIS 07,INST FEDERATIF RECH CELLULES EPITHELIALES,INSERM,U426 F-75870 PARIS 18 FRANCE
Titolo Testata:
The Journal of biological chemistry
fascicolo: 52, volume: 272, anno: 1997,
pagine: 32919 - 32924
SICI:
0021-9258(1997)272:52<32919:TROSBV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL COLLECTING DUCT; NA+-K+-ATPASE; MESSENGER-RNA EXPRESSION; RAT-KIDNEY; INSITU HYBRIDIZATION; BINDING PROTEINS; RESPONSE ELEMENT; GENE-EXPRESSION; ALPHA-SUBUNITS; GAMMA-SUBUNITS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S. Djelidi et al., "TRANSCRIPTIONAL REGULATION OF SODIUM-TRANSPORT BY VASOPRESSIN IN RENAL-CELLS", The Journal of biological chemistry, 272(52), 1997, pp. 32919-32924

Abstract

We base examined whether arginine vasopressin (AVP) can induce a long-term modulation of transepithelial ion transport in addition to its well known shortterm effect, In the RCCD1 rat cortical collecting duct cell line, an increase in both short-circuit current and Na-22 transport was observed after several hours of 10(-8) M AVP treatment (a concentration above the in vivo physiological range), This delayed effect was partially prevented by apical addition of 10(-5) M amiloride and was blocked by 10(-6) M actinomycin D and 2 x 10(-6) hr cycloheximide. The amounts of mRNA encoding the alpha(1) (not beta(1)) subunit of Na+/K+-ATPase and the beta and gamma (not alpha) subunits of the amiloride-sensitive epithelial Na+ channel were significantly increased by AVP treatment, The increase in mRNA was blocked by actinomycin D, not by amiloride, suggesting a Na+-independent increase in the rate of transcription of these subunits, The translation rates of the alpha(1) subunit of Na+/K+-ATPase and the beta and gamma subunits of the rat epithelial sodium channel increased significantly, whereas the translation rates of the other subunits remained unchanged, Finally, the number of Na channels present in the apical membrane of the cells increased, as demonstrated by enhanced specific [H-3]phenamil binding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:48:55