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Titolo:
ORAL PASSIVE-IMMUNIZATION AGAINST EXPERIMENTAL SALMONELLOSIS IN MICE USING CHICKEN EGG-YOLK ANTIBODIES SPECIFIC FOR SALMONELLA-ENTERITIDIS AND SALMONELLA-TYPHIMURIUM
Autore:
YOKOYAMA H; UMEDA K; PERALTA RC; HASHI T; ICATLO FC; KUROKI M; IKEMORI Y; KODAMA Y;
Indirizzi:
IMMUNOL RES INST GIFU,839-1 SANO GIFU 50111 JAPAN
Titolo Testata:
Vaccine
fascicolo: 4, volume: 16, anno: 1998,
pagine: 388 - 393
SICI:
0264-410X(1998)16:4<388:OPAESI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEINS; CULTURED EPITHELIAL-CELLS; TYPHI GIFU 10007; MOLECULAR CHARACTERIZATION; BACTERIAL ATTACHMENT; SIGNAL-TRANSDUCTION; HELA-CELLS; INVASION; PORINS; LIPOPOLYSACCHARIDE;
Keywords:
EGG YOLK ANTIBODY; PASSIVE IMMUNIZATION; SALMONELLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
H. Yokoyama et al., "ORAL PASSIVE-IMMUNIZATION AGAINST EXPERIMENTAL SALMONELLOSIS IN MICE USING CHICKEN EGG-YOLK ANTIBODIES SPECIFIC FOR SALMONELLA-ENTERITIDIS AND SALMONELLA-TYPHIMURIUM", Vaccine, 16(4), 1998, pp. 388-393

Abstract

The efficacy of chicken egg yolk homotypic antibodies specific for outer membrane proteins (OMP), lipopolysaccharide (LPS) or flagella (Fla) in controlling experimental salmonellosis in mice was investigated. Mice challenged orally with 2 x 10(9) c.f.u. of Salmonella enteritidisor 2 x 10(7) c.f.u. of S. typhimurium were orally treated with 0.2 mlanti-OMP, -LPS or -Fla yolk antibody three times a day for three consecutive days. In mice challenged with S. enteritidis, antibody treatment resulted in a survival rate of 80%, 47% and 60% using OMP, LPS or Fla specific antibodies respectively, in contrast to only 20% in control mice. In the S. typhimurium trial, survival rate was 40%, 30% and 20% using OMP, LPS or Fla specific antibodies respectively in contrast to 0% in control mice. In vitro adhesion of S. enteritidis and S. typhimurium to HeLa cells was significantly reduced by anti-AMP, -LPS, and -Fla homotypic antibodies. Results suggest that egg yolk antibodies specific for Salmonella OMP, LPS, and Fla may protect mice from experimental salmonellosis when passively administered orally. Of these antibodies, anti-OMP exhibited the highest level of protection in vivo and in vitro. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:26:37