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Titolo:
PLATELET STUDIES IN PANIC DISORDER - A REVIEW
Autore:
MANNION L; NUGENT D; LEONARD B;
Indirizzi:
NATL UNIV IRELAND UNIV COLL GALWAY,DEPT PSYCHIAT GALWAY IRELAND NATL UNIV IRELAND UNIV COLL GALWAY,DEPT PHARMACOL GALWAY IRELAND
Titolo Testata:
Irish journal of psychological medicine
fascicolo: 4, volume: 14, anno: 1997,
pagine: 139 - 143
SICI:
0790-9667(1997)14:4<139:PSIPD->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE ACTIVITY; AFFINITY BINDING-SITES; TRITIATED IMIPRAMINE BINDING; H-3 PAROXETINE BINDING; SEROTONIN UPTAKE; BLOOD-PLATELETS; )H-3>IMIPRAMINE BINDING; H-3-IMIPRAMINE BINDING; RECEPTOR-BINDING; AUTORADIOGRAPHIC LOCALIZATION;
Keywords:
ANXIETY DISORDERS; BLOOD PLATELETS; IMIPRAMINE; MONOAMINE OXIDASE; PANIC DISORDER; SEROTONIN;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
L. Mannion et al., "PLATELET STUDIES IN PANIC DISORDER - A REVIEW", Irish journal of psychological medicine, 14(4), 1997, pp. 139-143

Abstract

Objective: The blood platelet has been proposed as a model of centralneurons and may therefore be used as a peripheral marker of psychiatric illness. One method of investigating serotonin function in panic disorder has relied on the use of the platelet as a model of serotonergic neurons. This article reviews the studies of platelet function in panic disorder. Method: A literature search and review of relevant papers was undertaken. Result: Studies examining platelet serotonin uptake and concentration in panic disorder patients have to date yielded conflicting results, with some investigators reporting increased serotoninuptake, others reduced uptake. Similarly studies of platelet H-3-imipramine binding have also yielded conflicting results. Two studies of platelet H-3-paroxetine binding have shown a reduction in the density of binding sites (max) in patients with panic disorder. platelet monoamine oxidase activity in anxiety disorders has been reported to be increased by some investigators but decreased by others. Methodological considerations may have been responsible for these differences. Finally,studies of alpha(2) adrenoceptor density have also produced contrasting findings. Conclusion: The findings of these studies indicate that platelet function is altered in panic disorder. Such changes may allow an insight into the biochemical aetiology of the illness. Further studies are required to delineate the role of serotonin and non-adrenalinein panic disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:35:06