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Titolo:
LARGE VESSEL DYSFUNCTION IN DIABETIC ADOLESCENTS AND ITS RELATIONSHIPTO SMALL VESSEL COMPLICATIONS
Autore:
DONAGHUE KC; ROBINSON J; MCCREDIE R; FUNG A; SILINK M; CELERMAJER DS;
Indirizzi:
ROYAL ALEXANDRA HOSP CHILDREN,RAY WILLIAMS INST PAEDIAT ENDOCRINOL DIABET & MET,POB 3515 PARRAMATTA NSW 2124 AUSTRALIA ROYAL ALEXANDRA HOSP CHILDREN,RAY WILLIAMS INST PAEDIAT ENDOCRINOL DIABET & MET WESTMEAD NSW 2145 AUSTRALIA ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL SYDNEY NSW 2050 AUSTRALIA UNIV SYDNEY SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Journal of pediatric endocrinology & metabolism
fascicolo: 6, volume: 10, anno: 1997,
pagine: 593 - 598
SICI:
0334-018X(1997)10:6<593:LVDIDA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; HEALTHY-YOUNG ADULTS; GLYCEMIC CONTROL; MELLITUS; DISEASE; ATHEROSCLEROSIS; MORTALITY; CHILDREN; SMOKING; IDDM;
Keywords:
ADOLESCENTS; IDDM; ENDOTHELIAL FUNCTION; LARGE VESSEL DISEASE; MICROANGIOPATHY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.C. Donaghue et al., "LARGE VESSEL DYSFUNCTION IN DIABETIC ADOLESCENTS AND ITS RELATIONSHIPTO SMALL VESSEL COMPLICATIONS", Journal of pediatric endocrinology & metabolism, 10(6), 1997, pp. 593-598

Abstract

Endothelial dysfunction is considered a key early event in atherosclerosis, Using a novel ultrasound method, brachial artery endothelial and smooth muscle physiology were studied in 20 adolescents with IDDM and compared to that in 20 nondiabetic subjects matched for age (1322 years), gender and vessel size, Endothelium-dependent dilatation (EDD) was assessed in response to flow (EDD) and endothelium-independent vasodilatation after sublingual glyceryl trinitrate (GTN), Both EDD and GTN were reduced in those with IDDM compared with controls: 5% vs 9%, (p=0.0002) and 14% vs 21% (p=0.002), Abnormal EDD was found in 12 IDDM adolescents (diabetes duration 3.3-14.9 years), The maximum albumin excretion rate of the diabetic group was 17 mu g/min, Four adolescents had retinopathy assessed by stereoscopic fundus photography, Three had at least one of four cardiovascular autonomic test abnormalities, Therewas no significant correlation observed between the test for early large vessel disease and those for diabetic microangiopathy, Large vessel dysfunction was the most common abnormality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:51:01