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Titolo:
EFFECT OF NATIONWIDE VACCINATION OF 3-MONTH-OLD INFANTS IN THE NETHERLANDS WITH CONJUGATE HAEMOPHILUS-INFLUENZAE TYPE-B VACCINE - HIGH EFFICACY AND LACK OF HERD-IMMUNITY
Autore:
VANALPHEN L; SPANJAARD L; VANDERENDE A; SCHUURMAN I; DANKERT J;
Indirizzi:
NATL INST PUBL HLTH & ENVIRONM,LAB VACCINE DEV & MECHANISMS IMMUN,POB1 NL-3720 BA BILTHOVEN NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL,NATL REFERENCE LAB BACTERIAL MENINGITIS UVA RIVM NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of pediatrics
fascicolo: 6, volume: 131, anno: 1997,
pagine: 869 - 873
SICI:
0022-3476(1997)131:6<869:EONVO3>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OROPHARYNGEAL CARRIAGE; BACTERIAL-MENINGITIS; CHILDREN; POLYSACCHARIDE; COLONIZATION; ANTIBODIES; SUBTYPES; HIB;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
L. Vanalphen et al., "EFFECT OF NATIONWIDE VACCINATION OF 3-MONTH-OLD INFANTS IN THE NETHERLANDS WITH CONJUGATE HAEMOPHILUS-INFLUENZAE TYPE-B VACCINE - HIGH EFFICACY AND LACK OF HERD-IMMUNITY", The Journal of pediatrics, 131(6), 1997, pp. 869-873

Abstract

Objective: The effect of nationwide vaccination in The Netherlands with conjugate Haemophilus influenzae type b vaccine on the incidence ofH. influenzae meningitis was assessed in the first 3 years after the introduction of vaccination to the birth cohort at 3 months of age. Study design: Children in The Netherlands born after April 1, 1993, werevaccinated at the age of 3, 4, 5, and ii months. Children older than 3 months at the inception of the H. influenzae type b vaccination program were not immunized. The number of cases among the vaccine cohort was compared with the number in a historical control group of children born in the period April 1, 1990, and April 1, 1993. Results: The total number of patients with meningitis caused by H. influenzae type b reached a low, but constant level, that was expected for absence of herdimmunity. Among children in the vaccine era group 22 cases occurred, whereas among the historical control group (prevaccine era) 342 cases were found. In the vaccine era cohort, 2 patients with H. influenzae type b meningitis had been vaccinated three times, 13 received one or no vaccine dose because of their age, and 7 were not vaccinated for religious or logistic reasons. The number of cases among nonvaccinated children older than 3 years and the number of H influenzae meningitis cases caused by strains other than type b did not change.Conclusions: Conjugate H, influenzae type b vaccine prevents H. influenzae type b meningitis very effectively (99.4%) in children vaccinated twice or more. To reach rapid prevention of all H. influenzae type b disease simultaneous introduction of H. influenzae type b vaccination of children at various ages is recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 06:38:11