Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
WESTERN-BLOT-ANALYSIS OF THE IMMUNE-RESPONSE TO CANDIDA-ALBICANS ANTIGENS IN 391 LONG-TERM INTENSIVE-CARE PATIENTS
Autore:
WEIS C; KAPPE R; SONNTAG HG;
Indirizzi:
UNIV HEIDELBERG,INST HYG,NEUENHEIMER FELD 324 D-69120 HEIDELBERG GERMANY UNIV HEIDELBERG,INST HYG D-69120 HEIDELBERG GERMANY
Titolo Testata:
Mycoses
fascicolo: 5-6, volume: 40, anno: 1997,
pagine: 153 - 157
SICI:
0933-7407(1997)40:5-6<153:WOTITC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFICATION; DIAGNOSIS; SERA;
Keywords:
CANDIDA ALBICANS; IMMUNE RESPONSE; INTENSIVE CARE PATIENTS; WESTERN BLOT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Weis et al., "WESTERN-BLOT-ANALYSIS OF THE IMMUNE-RESPONSE TO CANDIDA-ALBICANS ANTIGENS IN 391 LONG-TERM INTENSIVE-CARE PATIENTS", Mycoses, 40(5-6), 1997, pp. 153-157

Abstract

The aim of this study was to determine, using Western blot, the prevalence of anti-Candida albicans antibodies in long-term intensive care patients and to characterize specific immune responses that may only occur in patients with invasive candidosis. A total of 1751 serum samples from 391 patients of a German multicentre study, which was designedto determine the incidence of systemic candidosis, was examined. Significantly enhanced antibody production against specific antigens was observed in several subgroups of patients, i.e. those with underlying disease of the pancreas (29 kDa, P = 0.006), cholecystolithiasis (47 kDa, P = 0.029), gastrointestinal tract disease (47 kDa, P = 0.03), steroid therapy (58 kDa, P = 0.02), thrush (58 kDa, P = 0.032), urogenitalinfection (58 kDa, P = 0.034), Candida antigen titre greater than or equal to 1:4 (58 kDa, P = 0.002) and positive fungal culture (36 kDa, P = 0.03) and those who had died (36 kDa, P = 0.011). In contrast to earlier publications, an immune response against the 29 and 47 kDa antigens was relatively common among long-term intensive care patients (37% and 70% antibody positive respectively). A single antigen that provided satisfactory sensitivity and specificity for the discrimination between fungal infection and no fungal infection or between superficial and invasive fungal infection was not identified in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:19:07