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Titolo:
EMBRYONIC CNS MACROPHAGES AND MICROGLIA DO NOT STEM FROM CIRCULATING,BUT FROM EXTRAVASCULAR PRECURSORS
Autore:
KURZ H; CHRIST B;
Indirizzi:
UNIV FREIBURG,ANAT INST 2,POB 111 D-79001 FREIBURG GERMANY
Titolo Testata:
Glia
fascicolo: 1, volume: 22, anno: 1998,
pagine: 98 - 102
SICI:
0894-1491(1998)22:1<98:ECMAMD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ENDOTHELIAL-CELLS; BLOOD-VESSELS; ORIGIN; ONTOGENY; BRAIN;
Keywords:
AVIAN EMBRYO; BLOOD VESSEL; CHICK-QUAIL CHIMERA; HEMATOPOIESIS; PARABIOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Kurz e B. Christ, "EMBRYONIC CNS MACROPHAGES AND MICROGLIA DO NOT STEM FROM CIRCULATING,BUT FROM EXTRAVASCULAR PRECURSORS", Glia, 22(1), 1998, pp. 98-102

Abstract

Invasion of mesoderm-derived cells into the developing spinal cord and brain has been shown to produce early central nervous system (CNS macrophage and microglia populations in avian embryos. A triplicate modeof entry has been proposed: through the endothelial wall of CNS bloodvessels; from the ventricular cavities; and through the pial surface. Invasion of circulating blood cells (monocytes) has not yet been proved in embryonic CNS. This report demonstrates: 1) the use of chick-quail blood chimeras by way of parabiosis (two embryos in one egg); 2) the use of QH1 monoclonal antibody for detection of quail cells circulating in chick blood vessels; 3) the presence of extravascular QH1-positive cells (macrophages) in E7-10 CNS in parabiosis quail, and their absence in parabiosis chick. We conclude that avian macrophages/microglia precursors do not penetrate through the wall of embryonic CNS vessels. In combination with published results, this finding strongly supports the view that invasion of migratory macrophages from the proliferation inside the CNS generate all microglia in avian embryos. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:54:16