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Titolo:
OPPOSITE EFFECTS OF RO-15-4513 ON ACQUISITION AND MAINTENANCE OF ETHANOL DRINKING BEHAVIOR IN MALE WISTAR RATS
Autore:
BUCZEK Y; TOMKINS DM; LE AD; SELLERS EM;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO ON M5S 2S1 CANADA ADDICT RES FDN TORONTO ON M5S 2S1 CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO ON CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA UNIV TORONTO,DEPT MED TORONTO ON CANADA
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 9, volume: 21, anno: 1997,
pagine: 1667 - 1675
SICI:
0145-6008(1997)21:9<1667:OEOROA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR ANTAGONIST; ALCOHOL-PREFERRING P; RO15-1788 FLUMAZENIL; DEPRIVED RATS; RO-15-4513; RO15-4513; AGONIST; STRESS; MEMORY; CONSUMPTION;
Keywords:
ANXIETY; SOCIAL INTERACTION; ETHANOL INTAKE; RO 15-4513; ETHANOL KINETICS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
Y. Buczek et al., "OPPOSITE EFFECTS OF RO-15-4513 ON ACQUISITION AND MAINTENANCE OF ETHANOL DRINKING BEHAVIOR IN MALE WISTAR RATS", Alcoholism, clinical and experimental research, 21(9), 1997, pp. 1667-1675

Abstract

Acute treatment with Ro 15-4513, a benzodiarepine receptor inverse agonist, has been consistently shown to suppress ethanol self administration behavior by rats, The aim of the present study was to examine theeffect of Ro 15-4513 on the acquisition and maintenance of ethanol drinking behavior in male Wistar rats, In rats maintained on a limited access procedure with a choice of 12% w/v ethanol solution and water, acute treatment with Ro 15-4513 (0.1 to 3.0 mg/kg) suppressed ethanol intake in a selective and dose-related manner (p < 0.01), However, by the fourth day of chronic Ro 15-4513 treatment, ethanol intake had returned to baseline levels. In contrast, chronic administration of Ro 15-4513 during the acquisition phase increased ethanol drinking behavior,compared with vehicle (p < 0.05), To assess whether the effects of Ro15-4513 on ethanol intake were due to an alteration in ethanol kinetics or on behavior, blood ethanol levels and rat social interaction behavior were also assessed, Neither acute nor chronic Ro 15-4513 treatment significantly altered ethanol kinetics after oral administration ofethanol (1.0 g/kg), but did suppress locomotor activity and time spent engaged in active social interaction at the 1.0 and 3.0 mg/kg doses,These results show. that Ro 15-4513 has opposite effects on ethanol consumption during the acquisition and maintenance phases of ethanol drinking behavior, suggesting that different mechanisms regulate Ro 15-4513's effects on acquisition and maintenance of ethanol intake, Ro 15-4513's reported anxiogenic or memory enhancing properties may be responsible for its effects on acquisition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:31:32