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Titolo:
ZINC ADMINISTRATION IMPROVES GASTRIC ALCOHOL-DEHYDROGENASE ACTIVITY AND FIRST-PASS METABOLISM OF ETHANOL IN ALCOHOL-FED RATS
Autore:
CABALLERIA J; GIMENEZ A; ANDREU H; DEULOFEU R; PARES A; CABALLERIA L; BALLESTA AM; RODES J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,DEPT BIOCHEM E-08036 BARCELONA SPAIN
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 9, volume: 21, anno: 1997,
pagine: 1619 - 1622
SICI:
0145-6008(1997)21:9<1619:ZAIGAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC LIPID-PEROXIDATION; 1ST-PASS METABOLISM; LIVER-DISEASE; COLLAGEN; STOMACH; TISSUE;
Keywords:
ZINC; ALCOHOL DEHYDROGENASE; FIRST-PASS METABOLISM OF ETHANOL; ALCOHOL-FED RATS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Caballeria et al., "ZINC ADMINISTRATION IMPROVES GASTRIC ALCOHOL-DEHYDROGENASE ACTIVITY AND FIRST-PASS METABOLISM OF ETHANOL IN ALCOHOL-FED RATS", Alcoholism, clinical and experimental research, 21(9), 1997, pp. 1619-1622

Abstract

The effects of zinc on first-pass metabolism (FPM) of ethanol and gastric and hepatic alcohol dehydrogenase (ADH) activities have been investigated in two groups of male Wistar rats fed a liquid ethanol diet with normal zinc content (7.6 mg/liter), or zinc supplemented (76 mg/liter), for 21 days, and in two pair-fed groups receiving the same dietswithout ethanol, Alcoholic rats with normal dietary zinc had lower FPM (1.64 +/- 0.25 vs, 2.43 +/- 0.20 mM x hr, p < 0.05) and gastric ADH activity (184 +/- 7 vs, 335 +/- 41 mu mol/min/mg protein, p < 0.01) than control rats. Zinc supplementation did not produce any change in FPM or in gastric ADH activity in control rats. By contrast, in alcoholic rats, the zinc supplement increased gastric ADH activity (247 +/- 31vs, 184 +/- 7 mu mol/min/mg protein, p < 0.05) and decreased the areas under the curve of blood ethanol concentrations after the intragastric administration of 0.25 g/kg of body weight of ethanol (0.78 +/- 0.07 vs, 1.71 +/- 0.24 mM x hr, p < 0.05), thereby increasing the FPM, Inconclusion, in alcohol-fed rats, the administration of zinc supplements restores gastric ADH activity and improves the FPM of ethanol, These effects may be one of the mechanisms in which zinc has a beneficial role in preventing the development of alcoholic hepatic lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:28:12