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Titolo:
II - FUNCTIONAL CONSEQUENCES OF INTRAGASTRICALLY ADMINISTERED ETHANOLIN RATS AS MEASURED BY THE 2-[C-14]DEOXYGLUCOSE METHOD - THE CONTRIBUTION OF DOPAMINE
Autore:
WILLIAMSHEMBY L; PORRINO LJ;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PHYSIOL & PHARMACOL,MED CTRBLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PHYSIOL & PHARMACOL WINSTONSALEM NC 27157
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 9, volume: 21, anno: 1997,
pagine: 1581 - 1591
SICI:
0145-6008(1997)21:9<1581:I-FCOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; PRECIPITATED MORPHINE-WITHDRAWAL; CEREBRAL GLUCOSE-UTILIZATION; VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; ANTIPSYCHOTIC-DRUGS; CONSCIOUS RAT; D1-DOPAMINE AGONIST; ENERGY-METABOLISM; BRAIN;
Keywords:
ETHANOL; CEREBRAL METABOLISM; DOPAMINE; FLUPENTIXOL;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
L. Williamshemby e L.J. Porrino, "II - FUNCTIONAL CONSEQUENCES OF INTRAGASTRICALLY ADMINISTERED ETHANOLIN RATS AS MEASURED BY THE 2-[C-14]DEOXYGLUCOSE METHOD - THE CONTRIBUTION OF DOPAMINE", Alcoholism, clinical and experimental research, 21(9), 1997, pp. 1581-1591

Abstract

As outlined in the companion paper, many of the changes in functionalactivity produced by acute intragastric ethanol administration as determined by the quantitative autoradiographic 2-[C-14]deoxyglucose method occur in structures of the mesocorticolimbic and nigrostriatal dopamine circuits. In this study, a dopaminergic antagonist, flupenthixol,was used to determine the contribution of dopamine to the ethanol-induced increases in functional activity. To assess the ability of flupenthixol to block dopaminergic-induced increases in glucose utilization,it was first examined in conjunction with the indirect dopaminergic agonist methylphenidate. Pretreatment with flupenthixol significantly reduced methylphenidate-induced increases in glucose utilization in structures of the mesocorticolimbic and nigrostriatal dopamine circuits. These findings indicate that this is an effective strategy for the determination of the neurochemical contributions to the changes in CNS functional activity. Flupenthixol pretreatment blocked many of the ethanol-induced increases in glucose utilization at the 0.25 g/kg dose, particularly in mesocorticolimbic and nigrostriatal structures, At the 1.0 and 2.0 g/kg ethanol doses, however, pretreatment with flupenthixol did not reverse the increases in glucose utilization in several brain regions, suggesting that dopaminergic activity is not responsible for the observed increases in glucose utilization and further, that these increases involve other neurotransmitter systems. In some regions, however, flupenthixol pretreatment resulted in augmented levels of glucose utilization above those rates produced by the administration of higher doses of ethanol alone. These findings suggest that the contribution of dopamine to the increases in functional activity are more complexat higher doses of ethanol.

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Documento generato il 29/03/20 alle ore 01:12:37