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Titolo:
ENDOTHELIAL-DERIVED VASORELAXATION IS IMPAIRED IN HUMAN APO A-I TRANSGENIC RABBITS
Autore:
LEBUFFE G; BOULLIER A; TAILLEUX A; DELFLY B; DUPUIS B; FRUCHART JC; DUVERGER N; EMMANUEL F; DENEFLE P; VALLET B; DURIEZ P;
Indirizzi:
INST PASTEUR,INSERM,U325,DEPT ATHEROSCLEROSE,1 RUE PROF CALMETTE,BP 245 F-59019 LILLE FRANCE INST PASTEUR,INSERM,U325,DEPT ATHEROSCLEROSE F-59019 LILLE FRANCE INST PASTEUR,FAC MED,PHARMACOL LAB F-59019 LILLE FRANCE UNIV LILLE 2,FAC PHARM LILLE FRANCE RHONE POULENC RORER GENCELL DIV VITRY SUR SEINE FRANCE
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 241, anno: 1997,
pagine: 205 - 211
SICI:
0006-291X(1997)241:1<205:EVIIIH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; DEPENDENT CORONARY VASOMOTION; NITRIC-OXIDE; L-ARGININE; HYPERCHOLESTEROLEMIC RABBIT; MEDIATED OXIDATION; CHOLESTEROL; INHIBITION; CELLS; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
G. Lebuffe et al., "ENDOTHELIAL-DERIVED VASORELAXATION IS IMPAIRED IN HUMAN APO A-I TRANSGENIC RABBITS", Biochemical and biophysical research communications, 241(1), 1997, pp. 205-211

Abstract

Endothelium-derived relaxing factor (nitric oxide: NO) may provide anendogenous defence against atherosclerosis which impairs endothelium dependent vascular relaxation. Atherosclerosis development is inhibited in cholesterol fed human apo A-I transgenic rabbits (Duverger, N., Circulation, 1996, 94, 713-717). We investigated if endothelium-dependent vascular relaxation is modified in human apo A-I transgenic rabbitsby testing in vitro endothelium-dependent receptor-dependent vascularrelaxation to acetylcholine and endothelium-dependent receptor independent vascular relaxation to A23187 of abdominal aorta, pre-contractedwith phenylephrine, in human apo A-I transgenic rabbits (n=4) versus non transgenic littermates (n=4). Endothelium-independent vascular relaxation was investigated with sodium nitroprusside. Vascular precontraction to phenylephrine was significantly increased in human apo A-I transgenic rabbits (p<0.05) while endothelium-independent vascular relaxation to nitroprusside was similar between human apo A-I transgenic rabbits and control rabbits. Endothelium-dependent receptor-dependent and receptor-independent vascular relaxations were reduced in human apo A-I transgenic rabbits (p<0.05). Maximum endothelium-dependent receptor-dependent vascular relaxation was negatively correlated with HDL-cholesterol and total apo A-I (rabbit + human) plasma levels (r=0.87 and 0.86, p=0.01, respectively) but not with atherogenic plasma lipid (VLDL-cholesterol, LDL-cholesterol, VLDL+LDL cholesterol, triglycerides, apolipoprotein B) levels. These results suggest that the transgenesis of human apo A-I in rabbits impairs signal transduction of endothelial NO synthesis. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:43:37