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Titolo:
P19 EMBRYONAL CARCINOMA-CELLS - A MODEL SYSTEM FOR STUDYING NEURAL-TUBE INDUCTION OF SKELETAL MYOGENESIS
Autore:
ANGELLO JC; STERN HM; HAUSCHKA SD;
Indirizzi:
UNIV WASHINGTON,DEPT BIOCHEM,BOX 357350 SEATTLE WA 98195
Titolo Testata:
Developmental biology
fascicolo: 1, volume: 192, anno: 1997,
pagine: 93 - 98
SICI:
0012-1606(1997)192:1<93:PEC-AM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BHLH GENE-EXPRESSION; NEURONAL DIFFERENTIATION; MUSCLE DIFFERENTIATION; PARAXIAL MESODERM; AXIAL STRUCTURES; SOMITES; NOTOCHORD; SIGNALS; MYOD; LIMB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Angello et al., "P19 EMBRYONAL CARCINOMA-CELLS - A MODEL SYSTEM FOR STUDYING NEURAL-TUBE INDUCTION OF SKELETAL MYOGENESIS", Developmental biology, 192(1), 1997, pp. 93-98

Abstract

A model experimental system for investigating myogenic induction signals has been devised with mouse P19 embryonal carcinoma cells. When cocultured with pieces of chick neural tube, aggregated P19 cells are induced to become skeletal muscle. The most potent inducing activity is localized to the dorsal neural tube. Less activity was found in the ventral neural tube, notochord, ectoderm, and lateral plate mesoderm, and none was detected in the neural retina. These results suggest that P19 cells may be a useful model system for investigating the mechanismsunderlying induction of somite myogenesis. (C) 1997 Academic Press.

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Documento generato il 24/09/20 alle ore 22:53:49