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Titolo:
GENETIC-ANALYSIS OF BETA-1 INTEGRIN FUNCTION - CONFIRMED, NEW AND REVISED ROLES FOR A CRUCIAL FAMILY OF CELL-ADHESION MOLECULES
Autore:
BRAKEBUSCH C; HIRSCH E; POTOCNIK A; FASSLER R;
Indirizzi:
MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY LUND UNIV,DEPT EXPT PATHOL S-22185 LUND SWEDEN MAX PLANCK INST IMMUNBIOL D-79108 FREIBURG GERMANY
Titolo Testata:
Journal of Cell Science
, volume: 110, anno: 1997,
parte:, 23
pagine: 2895 - 2904
SICI:
0021-9533(1997)110:<2895:GOBIF->2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CARCINOMA CELLS; EXTRACELLULAR-MATRIX; FIBRONECTIN RECEPTOR; STEM-CELLS; SKELETAL-MUSCLE; ALPHA(5)BETA(1) INTEGRIN; EXPERIMENTAL METASTASIS; CYTOPLASMIC DOMAINS; ALPHA(V) INTEGRINS; SYNTHETIC PEPTIDES;
Keywords:
BETA-1 INTEGRIN; HOMOLOGOUS RECOMBINATION; DIFFERENTIATION; MORPHOGENESIS;
Tipo documento:
Editorial Material
Natura:
Periodico
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
C. Brakebusch et al., "GENETIC-ANALYSIS OF BETA-1 INTEGRIN FUNCTION - CONFIRMED, NEW AND REVISED ROLES FOR A CRUCIAL FAMILY OF CELL-ADHESION MOLECULES", Journal of Cell Science, 110, 1997, pp. 2895-2904

Abstract

Integrins are heterodimeric cell adhesion proteins connecting the extracellular matrix to the cytoskeleton and transmitting signals in bothdirections, These integrins are suggested to be involved in many different biological processes such as growth, differentiation, migration,and cell death, Of more than 20 known integrins, 10 contain the nearly ubiquitously expressed beta 1 integrin subunit, Disruption of the beta 1 integrin gene by homologous recombination allows us to assess thesupposed functions of beta 1 containing integrins in vivo in a new way, This review will present and discuss recent findings derived from such studies concerning the biological roles of beta 1 integrins in early development, differentiation and migration, hematopoiesis, tumorigenesis, and supramolecular assembly of extracellular matrix proteins, While several former results were confirmed, others were contradicted and new functions found, significantly changing the previous view of beta 1 integrin function in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:36:45