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Titolo:
INCREASED STIFFNESS OF RADIAL ARTERY WALL MATERIAL IN END-STAGE RENAL-DISEASE
Autore:
MOURAD JJ; GIRERD X; BOUTOUYRIE P; LAURENT S; SAFAR M; LONDON G;
Indirizzi:
HOP BROUSSAIS,DEPT INTERNAL MED,96 RUE DIDOT F-75674 PARIS 14 FRANCE HOP BROUSSAIS,DEPT INTERNAL MED F-75674 PARIS 14 FRANCE HOP BROUSSAIS,INSERM,U337 F-75674 PARIS 14 FRANCE MANHES CTR F-91700 FLEURY MEROGIS FRANCE
Titolo Testata:
Hypertension
fascicolo: 6, volume: 30, anno: 1997,
pagine: 1425 - 1430
SICI:
0194-911X(1997)30:6<1425:ISORAW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSIVE PATIENTS; DISTENSIBILITY; HYPERTROPHY; HUMANS;
Keywords:
ARTERIES; RENAL DISEASE; HYPERTENSION, ESSENTIAL; ULTRASONOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Mourad et al., "INCREASED STIFFNESS OF RADIAL ARTERY WALL MATERIAL IN END-STAGE RENAL-DISEASE", Hypertension, 30(6), 1997, pp. 1425-1430

Abstract

The incremental elastic modulus (fine), which is the slope of the relationship between stress and strain of arteries, is a marker of vascular wall material stiffness. Isobaric fine is reduced at the site of the radial artery in patients with essential hypertension and increased at the site of the common carotid artery in subjects with end-stage renal disease (ESRD). Whether the changes in fine are influenced by the topography of the vessels, the composition of the arterial wall, and/or by the presence of ESRD is largely ignored. Radial artery fine was measured in 19 patients with ESRD and compared with the fine of 89 subjects with essential hypertension and 20 normotensive control subjects. Transcutaneous measurements of radial artery internal diameter and wall thickness (echo-tracking device) and digital pulse pressure (Finapres) were allowed to calculate fine under operational tie, at the mean arterial pressure of each group) and isobaric (100 mm Hg) conditions, as well as for a given wall stress. Internal diameter and pulsatile changes in diameter were identical in the three groups. Wall thickness and mean blood pressure were significantly elevated in subjects with hypertension but not in ESRD patients. Circumferential wall stress was identical in the three groups. For the same operational wall stress, and therefore at the operational mean arterial pressure of each group, fine (kPa . 10(3)) was increased in patients with ESRD (5.53+/-4.0 versus 3.3+/-2.4 in control subjects; P<.05) and normal in subjects with essential hypertension (3.87+/-4.0). Under isobaric conditions, fine was also significantly lower in subjects with hypertension and elevated in patients with ESRD. Thus, at the site of a medium-sized muscular artery constantly devoid of atherosclerosis, the stiffness of wall material is increased in patients with ESRD. The demonstrated alterations of the arterial wall are independent of the level of blood pressure andtensile stress and should be related to the status ESRD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:11:09