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Titolo:
INTERLEUKIN-12-ACTIVATED NATURAL-KILLER-CELLS RECOGNIZE B7 COSTIMULATORY MOLECULES ON TUMOR-CELLS AND AUTOLOGOUS DENDRITIC CELLS
Autore:
GELDHOF AB; MOSER M; LESPAGNARD L; THIELEMANS K; DEBAETSELIER P;
Indirizzi:
FREE UNIV BRUSSELS,IMOL 2,VIB,CELLULAR IMMUNOL LAB,PAARDENSTR 65 B-1640 RHODE ST GENESE BELGIUM FREE UNIV BRUSSELS,FLANDERS INTERUNIV INST BIOTECHNOL,CELLULAR IMMUNOL LAB B-1640 RHODE ST GENESE BELGIUM FREE UNIV BRUSSELS,PHYSIOL ANIM LAB RHODE ST GENESE BELGIUM VUB,SCH MED,PHYSIOL LAB JETTE BELGIUM
Titolo Testata:
Blood
fascicolo: 1, volume: 91, anno: 1998,
pagine: 196 - 206
SICI:
0006-4971(1998)91:1<196:INRBC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX CLASS-I; EFFECTIVE ANTITUMOR IMMUNITY; STIMULATORY FACTOR NKSF; T-LYMPHOMA-CELLS; MEDIATED CYTOTOXICITY; INTERFERON-GAMMA; EXPRESSION; RECEPTOR; CYTOKINE; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Geldhof et al., "INTERLEUKIN-12-ACTIVATED NATURAL-KILLER-CELLS RECOGNIZE B7 COSTIMULATORY MOLECULES ON TUMOR-CELLS AND AUTOLOGOUS DENDRITIC CELLS", Blood, 91(1), 1998, pp. 196-206

Abstract

Activation of natural killer (NK) cells in the presence of interleukin-12 (IL-12) augments the capacity of these effector cells to recognize B7-1- and B7-2-expressing target cells. These effector cells also efficiently lyse autologous B7-positive progenitor or organ-derived dendritic cells, suggesting a physiologic regulatory pathway between IL-12, NK cells, and B7-expressing antigen-presenting cells, Although IL-12-activated NK cells secreted higher levels of interferon-gamma, this cytokine did not play a role in synergistic effects of IL-12 and B7 on NK activation, The B7-counterreceptor was found to be selectively upregulated on IL-2/IL-12 as compared with IL-2-activated NK cells, CD28 is functionally involved in the recognition of B7 an target cells sinceIL-2/IL-12-activated NK cells derived from CD28 knockout mice were strongly reduced in their capacity to lyse syngeneic B7-positive tumor cells as well as antigen-presenting cells. However, recognition of B7 on allogeneic targets did not require the expression of CD28 on the IL-2/IL-12-activated NK cells, Hence, IL-12 triggers the expression of both CD28-dependent and CD28-independent mechanisms that allow NK cells to eliminate B7-positive target cells including autologous dendritic cells. (C) 1998 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:52:55