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Titolo:
DIFFERENTIAL EXPRESSION OF THE TFF-PEPTIDES XP1 AND XP4 IN THE GASTROINTESTINAL-TRACT OF XENOPUS-LAEVIS
Autore:
JAGLA W; WIEDE A; KOLLE S; HOFFMANN W;
Indirizzi:
OTTO VON GUERICKE UNIV KLINIKUM,INST MOL BIOL & MED CHEM,LEIPZIGER STR 44 D-39120 MAGDEBURG GERMANY OTTO VON GUERICKE UNIV KLINIKUM,INST MOL BIOL & MED CHEM D-39120 MAGDEBURG GERMANY MAX PLANCK INST PSYCHIAT,NEUROCHEM ABT D-82152 MARTINSRIED GERMANY
Titolo Testata:
Cell and tissue research
fascicolo: 1, volume: 291, anno: 1998,
pagine: 13 - 18
SICI:
0302-766X(1998)291:1<13:DEOTTX>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SPASMOLYTIC POLYPEPTIDE; MUCOUS NECK CELLS; TREFOIL PEPTIDES; P-DOMAIN; GASTRIC-MUCOSA; STOMACH MUCOSA; MICE LACKING; FUNDIC GLAND; PS2; MIGRATION;
Keywords:
TFF-DOMAIN; MUCIN; MUCOUS NECK CELL; STOMACH; INTESTINE; ESOPHAGUS; XENOPUS LAEVIS (ANURA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W. Jagla et al., "DIFFERENTIAL EXPRESSION OF THE TFF-PEPTIDES XP1 AND XP4 IN THE GASTROINTESTINAL-TRACT OF XENOPUS-LAEVIS", Cell and tissue research, 291(1), 1998, pp. 13-18

Abstract

TFF-peptides (formerly P-domain peptides, trefoil factors) represent major secretory products of the mammalian gastrointestinal tract. A molecular cloning approach revealed the existence of two TFF-peptides, xP1 and xP4, also in the stomach of Xenopus laevis. Here, the localization of these two peptides by Western blot analysis as well as immunohistochemistry is presented. xP1 is found predominantly in the surface mucous cells of the stomach, whereas xP4 is mainly localized to a specific population of goblet cells in the esophagus, to mucous neck cells of the stomach, and to closely resembling cells in antral glands, xP4 in the esophagus and in the stomach differ by their N-glycosylation patterns. Compared to mammalian TFF-peptides, xP1 obviously represents the frog homologue of human TFF1 (formerly pS2) and xP4 seems to be theamphibian equivalent of human TFF2 (formerly hSP).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:00:21