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Titolo:
SMALL AND NEUTRAL (TCO)-O-V BAT, BISAMINOETHANETHIOL (N2S2) COMPLEXESFOR DEVELOPING NEW BRAIN IMAGING AGENTS
Autore:
OYA S; PLOSSL K; KUNG MP; STEVENSON DA; KUNG HF;
Indirizzi:
3700 MARKET ST,ROOM 305 PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIOL PHILADELPHIA PA 19104
Titolo Testata:
Nuclear medicine and biology
fascicolo: 2, volume: 25, anno: 1998,
pagine: 135 - 140
SICI:
0969-8051(1998)25:2<135:SAN(BB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TC-99M; BIODISTRIBUTION; LIGANDS;
Keywords:
EXCHANGE REACTION; HPLC; LIGAND EXCHANGE; RADIOLABELING; RADIOCHEMICAL PURITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S. Oya et al., "SMALL AND NEUTRAL (TCO)-O-V BAT, BISAMINOETHANETHIOL (N2S2) COMPLEXESFOR DEVELOPING NEW BRAIN IMAGING AGENTS", Nuclear medicine and biology, 25(2), 1998, pp. 135-140

Abstract

Bisaminoethanethiol (BAT) ligands with various gem-dimethyl and amidegroups were prepared, and the corresponding neutral Tc-99m complexes were prepared and evaluated for their relative stabilities by ligand-exchange reactions, It was demonstrated that technetium complexes containing gemdimethyl substituents have higher lipophilicities, whereas those with an amide group possess greater stability, which enhances ligand-exchange reaction. The most interesting observation was that the brain uptake in rats is not determined only by lipophilicity. Apparently, Tc-99m complexes with an amide functional group display lower brain uptakes in rats compared to those without an amide group. The brain uptake was strongly influenced by substituents on the BAT ligand. These factors are critically important and should be taken into consideration when designing Tc-99m-labeled agents for CNS receptor imaging, (C) 1998 Elsevier Science Inc.

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Documento generato il 26/01/20 alle ore 09:57:50