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Titolo:
THE EFFECTS OF CHRONIC SMOKING ON THE FIBRINOLYTIC POTENTIAL OF PLASMA AND PLATELETS
Autore:
SIMPSON AJ; GRAY RS; MOORE NR; BOOTH NA;
Indirizzi:
UNIV EDINBURGH,SCH MED,RAYNE LAB,RESP MED UNIT,TEVIOT PL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND ST JOHNS HOSP,DEPT MED LIVINGSTON SCOTLAND UNIV ABERDEEN,DEPT MOL & CELL BIOL ABERDEEN SCOTLAND
Titolo Testata:
British Journal of Haematology
fascicolo: 1, volume: 97, anno: 1997,
pagine: 208 - 213
SICI:
0007-1048(1997)97:1<208:TEOCSO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; CIGARETTE-SMOKING; MYOCARDIAL-INFARCTION; INSULIN RESISTANCE; T-PA; PAI-1; SMOKERS; DISEASE; RELEASE; RISK;
Keywords:
SMOKING; TISSUE-TYPE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1; PLASMA; PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Simpson et al., "THE EFFECTS OF CHRONIC SMOKING ON THE FIBRINOLYTIC POTENTIAL OF PLASMA AND PLATELETS", British Journal of Haematology, 97(1), 1997, pp. 208-213

Abstract

We studied tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor typ 1 (PAI-1) in healthy individuals divided by smoking habit into current smokers, former smokers and non-smokers (who had never smoked). Plasma PAI-1 antigen was significantly higher in smokers than in non-smelters with intermediate levels in former smokers. A similar trend was observed for plasma PAI activity but this did not reach statistical significance. Platelet PAI-1 and plasma t-PA were not significantly different when comparing the three groups. After venous occlusion t-PA rose significantly in all groups; no significant change in plasma PAI-1 was observed. The ratio of t-PA to PAI-1 in plasma was similar in non-smokers and former smokers but lower in smelters, suggesting that there is at least partial restoration of plasma fibrinolytic potential after smoking cessation. Plasma PAI-1 antigen and PAI activity correlated with estimated pack-years of cigarettes smoked among smokers and former smokers. When all subjects were studied collectively plasma PAI-1 correlated strongly with plasma t-PA and triglycerides; plasma t-PA also correlated strongly with triglycerdes. We conclude that chronic smoking is associated with impaired fibrinolysis in plasma and that this largely reflects elevated plasma PAI-1 in smelters. Smoking does not appear to affect the response to venous occlusion. The postulated effect of chronic smoking on plasma PAI-1 may be mediatedby the influence of smoking on triglycerides and insulin resistance. Stopping smoking appears to return impaired fibrinolysis towards normal. Smoking does not quantitatively affect the platelet pool of PAI-I. Smoking habit should be controlled for in clinical analyses of PAI-1 and t-PA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:01:00