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Titolo:
INTERRENAL DYSFUNCTION IN FISH FROM CONTAMINATED SITES - IN-VIVO AND IN-VITRO ASSESSMENT
Autore:
HONTELA A;
Indirizzi:
UNIV QUEBEC,TOXEN RES CTR,DEPT SCI BIOL MONTREAL PQ H3C 3P8 CANADA
Titolo Testata:
Environmental toxicology and chemistry
fascicolo: 1, volume: 17, anno: 1998,
pagine: 44 - 48
SICI:
0730-7268(1998)17:1<44:IDIFFC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TILAPIA OREOCHROMIS-MOSSAMBICUS; SALMON ONCORHYNCHUS-KISUTCH; JUVENILE RAINBOW-TROUT; PLASMA-CORTISOL; COHO SALMON; PHYSIOLOGICAL-RESPONSES; STRESS RESPONSES; PERCA-FLAVESCENS; YELLOW PERCH; MYKISS;
Keywords:
CORTICOSTEROIDS; INTERRENAL; XENOBIOTICS; FISH; AMPHIBIANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Hontela, "INTERRENAL DYSFUNCTION IN FISH FROM CONTAMINATED SITES - IN-VIVO AND IN-VITRO ASSESSMENT", Environmental toxicology and chemistry, 17(1), 1998, pp. 44-48

Abstract

Cortisol, synthesized in the interrenal cells of teleost head kidney,has a major role in the physiologic response to physical and chemicalstressors. Plasma levels of cortisol increase in physiologically competent fish acutely exposed to stressors such as cadmium or mercury. The effects of chronic low level exposures are less well understood. We have diagnosed an endocrine impairment characterized by a reduced capacity to elevate plasma cortisol levels in response to an acute standardized capture stress in yellow perch (Perca flavescens) and in northern pike (Esox lucius) sampled at sites contaminated by mixtures of pollutants (heavy metals, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls), by heavy metals, or by bleached kraft mill effluent. Our studies with fish, as well as with amphibians at contaminated sites, demonstrated that low level chronic exposures impair secretion of corticosteroids. We have developed new tests for assessment of the functional integrity of teleost and amphibian interrenal tissue by using an adrenocorticotropic hormone (ACTH) challenge, in vivo and in vitro. The reduced ability to respond to ACTH indicates that the normal neuroendocrine response to stressors may be disrupted and that the abilityto cope with biotic and abiotic stressors in the environment may be significantly reduced in the impaired animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:06:55