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Titolo:
AUTOIMMUNE PROSTATITIS - EVIDENCE OF T-CELL REACTIVITY WITH NORMAL PROSTATIC PROTEINS
Autore:
ALEXANDER RB; BRADY F; PONNIAH S;
Indirizzi:
VET ADM MED CTR,UROL SECT,10 N GREENE ST BALTIMORE MD 21201 VA MARYLAND HLTH CARE SYST,UROL SECT BALTIMORE MD 00000 UNIV MARYLAND,SCH MED,DIV UROL BALTIMORE MD 21201
Titolo Testata:
Urology
fascicolo: 6, volume: 50, anno: 1997,
pagine: 893 - 899
SICI:
0090-4295(1997)50:6<893:AP-EOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ABACTERIAL PROSTATITIS; NONBACTERIAL PROSTATITIS; CHLAMYDIA-TRACHOMATIS; HYPERPLASIA; INFLAMMATION; SYMPTOMS; SEARCH; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Alexander et al., "AUTOIMMUNE PROSTATITIS - EVIDENCE OF T-CELL REACTIVITY WITH NORMAL PROSTATIC PROTEINS", Urology, 50(6), 1997, pp. 893-899

Abstract

Objectives. To determine whether men with chronic prostatitis/chronicpelvic pain syndrome have evidence of an autoimmune response to prostatic proteins. We examined men with a history of chronic prostatitis/ chronic pelvic pain syndrome for evidence of T lymphocyte reactivity to seminal plasma. Methods. Patients underwent automated leukopheresis to obtain peripheral blood mononuclear cells. We performed a recall antigen proliferation assay to detect specific proliferation of peripheral helper T lymphocytes in men with chronic prostatitis/chronic pelvicpain syndrome and compared the results with those of normal men. The antigen for these studies consisted of seminal plasma from normal donors and men with seminal vesicle atresia. Results. A specific recall proliferative response to seminal plasma was observed in 3 of 10 men with a history of chronic prostatitis/chronic pelvic pain syndrome compared with none of 15 normal men. The CD4 T cell proliferative response to seminal plasma was statistically significant when compared with medium alone in men with a history of chronic prostatitis/chronic pelvic pain syndrome but it was not statistically significant in normal men. The recall responses of both the chronic prostatitis/chronic pelvic pain syndrome group and normal subjects to the recall antigens tetanus toroid and Candida extract were equivalent. Conclusions. The data represent the first direct evidence that some men with chronic prostatitis/chronic pelvic pain syndrome have an autoimmune component to their disease. Autoimmunity is a potential etiology for chronic nonbacterial prostatitis. (C) 1997, Elsevier Science inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:21:49